نتایج جستجو برای: ipah gene
تعداد نتایج: 1141692 فیلتر نتایج به سال:
BACKGROUND Gene expression profiling of peripheral blood mononuclear cells (PBMCs) is a powerful tool for the identification of surrogate markers involved in disease processes. The hypothesis tested in this study was that chronic exposure of PBMCs to a hypertensive environment in remodeled pulmonary vessels would be reflected by specific transcriptional changes in these cells. METHODOLOGY/PRI...
The release of endogenous prostacyclin (PGI2) is depressed in patients with pulmonary arterial hypertension (PAH). PGI2 replacement therapy by epoprostenol infusion is one of the best treatments available for PAH. Here, we provide an overview of the current clinical data for epoprostenol. Epoprostenol treatment improves symptoms, exercise capacity, and hemodynamics, and is the only treatment th...
Earlier electron microscopic data had shown that a hallmark of the vascular remodeling in pulmonary arterial hypertension (PAH) in man and experimental models includes enlarged vacuolated endothelial and smooth muscle cells with increased endoplasmic reticulum and Golgi stacks in pulmonary arterial lesions. In cell culture and in vivo experiments in the monocrotaline model, we observed disrupti...
The products of the ipaB, ipaC, and ipaD genes are involved in the expression of the invasive phenotype in all species of Shigella and enteroinvasive Escherichia coli (EIEC). DNA probes derived from these genes are accurate indicators of the invasive phenotype (M. Venkatesan, J. M. Buysse, E. V. Vandendries, and D. J. Kopecko, J. Clin. Microbiol. 26:261-266, 1988); however, spontaneous loss of ...
Adaptation of the right ventricle (RV) to increased afterload is crucial for survival in pulmonary hypertension (PH), but it is challenging to assess RV function and identify associated molecular mechanisms. The aim of the current study was to analyze the relationship between invasive and noninvasive parameters of RV morphology and function and associated molecular changes. The response of mice...
This study aimed to investigate the distribution of virulence factor genes in Shigella strains isolated from children with diarrhea southwest, Iran. In this cross-sectional study, 1530 diarrheal stool specimens were collected aged under 15 years. The identified by biochemical methods and polymerase chain reaction (PCR). Subsequently, all isolates evaluated PCR for presence nine ipaH (responsibl...
BACKGROUND In Malaysia, Shigella spp. was reported to be the third commonest bacterial agent responsible for childhood diarrhoea. Currently, isolation of the bacterium and confirmation of the disease by microbiological and biochemical methods remain as the "gold standard". This study aimed to detect the prevalence of four Shigella virulence genes present concurrently, in randomly selected Malay...
conclusions ipah is associated with subclinical hypothyroidism and low patient functional capacity, and is more common in rv failure. results in this research, 84.8% of the participants were women. the mean pap was 51.6 mmhg (31-87) and mean thyroid stimulating hormone (tsh) level was 4.2 miu/ml (0.7 - 10). subclinical hypothyroidism was detected in 26 patients (49.1%). there were significant c...
Shigella spp. are exquisitely fastidious gram-negative organisms which frequently escape detection by traditional culture methods. To get a more complete understanding of the disease burden caused by Shigella in Nha Trang, Vietnam, real-time PCR was used to detect Shigella DNA. Randomly selected rectal swab specimens from 60 Shigella culture-positive patients and 500 Shigella culture-negative p...
هدف: شیگلوزیس یکی از علتهای اصلی مرگ و میر کودکان مبتلا به اسهال در کشورهای در حال توسعه است. بررسی مقاومت آنتیبیوتیکی این باکتری از اهمیت زیادی برخوردار است. ژن ipah یکی از ژنهای ویرولانس است که میتواند بهعنوان شناساگر در تشخیص شیگلا بکار رود. مواد و روشها: در مجموع 100 نمونه شیگلا از نقاط مختلف ایران جمعآوری شد. این سویهها با آزمونهای بیوشیمیایی و سرولوژیکی برای 4 گونه دیسانتری، سونئ...
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