irak4

AIM To study the innate immune function in ulcerative colitis (UC) patients who fail to respond to anti-tumor necrosis factor (TNF) therapy. METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell (PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF th...

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Ktx-120, a Novel Irakimid Degrader of IRAK4 and IMiD Substrates Shows Preferential Activity and Induces Regressions in MYD88-Mutant DLBCL CDX and PDX Models

Journal: :Blood 2020

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Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017

Sam Strickson Christoph H Emmerich Eddy T H Goh Jiazhen Zhang Ian R Kelsall Thomas Macartney C James Hastie Axel Knebel Mark Peggie Francesco Marchesi J Simon C Arthur Philip Cohen

It is widely accepted that the essential role of TRAF6 in vivo is to generate the Lys63-linked ubiquitin (K63-Ub) chains needed to activate the "master" protein kinase TAK1. Here, we report that TRAF6 E3 ligase activity contributes to but is not essential for the IL-1-dependent formation of K63-Ub chains, TAK1 activation, or IL-8 production in human cells, because Pellino1 and Pellino2 generate...

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