OBJECTIVES Iran is considered as one of the high-prevalence areas for β-thalassemia with a rate of about 10% carrier frequency. Molecular diagnosis of the disease is performed both by direct sequencing and indirectly by the use of polymorphic markers present in the beta globin gene cluster. However, to date there is no reliable information on the application of the markers in the Iranian popula...

Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5. Macrophages, NK cells and T lymphocytes express CCR5 and thus, affected CCR5 expression or functions could be associated with altered immune responses. Deletion of 32 base pair...

Abstract—Wheat is the first and the most important grain of the world and its bakery property is due to glutenin and gliadin qualities. Wheat seed proteins were divided into four groups according to solubility including albumin, globulin, glutenin and prolamin or gliadin. Gliadins are major components of the storage proteins in wheat endosperm. It seems that little information is available abou...

objective macular corneal dystrophy (mcd) is a rare autosomal recessive disorder affecting the stroma of cornea. most cases of mcd are caused by mutations in chst6 gene. the aim of this study was to determine mutations in the carbohydrate sulfotransferase 6 gene (chst6) through genetic analysis of 7 iranian patients with mcd. materials & methods we screened the chst6 gene to determine the range...

objective(s): iran is considered as one of the high-prevalence areas for β-thalassemia with a rate of about 10% carrier frequency. molecular diagnosis of the disease is performed both by direct sequencing and indirectly by the use of polymorphic markers present in the beta globin gene cluster. however, to date there is no reliable information on the application of the markers in the iranian pop...

congenital generalized lipodystrophies (cgls) are very rare autosomal recessive disorders which have four types.of the four cgl types, bscl2 (berardinelli–seip congenital lipodystrophy type 2) is the result of mutations in the bscl2/seipingene.bscl2 which is the most severe lipodystrophic phenotype is characterized by generalized lipodystrophy, overgrowth,acanthosisnigricans, hepatomegaly, insu...

BACKGROUND Phenylalanine hydroxylase (PAH) gene is the well-known causative gene for classic Phenylketonuria (PKU) (OMIM#261600) disease, with more than 500 reported mutations. Through this study, a novel mutation in the PAH gene in an Iranian pedigree with phenylketonuria was introduced. METHODS A consanguineous family with a 10-year old affected girl was referred for genetic analysis. Mutat...

The application of isolated plant tissue and organs is getting more actual along with traditionalplant ex situ conservation methods. peculiarities hormon regulation morphogenesis have been established fora Hedysarum razoumovianum cultivation. Optimal concentrations growth regulators for stages induction explantdevelopment, microshoots regeneration their rooting chosen. development reproduction ...

objective: survey of molecular characterization of nucleoprotein gene of h9n2 avian influenza viruses and determination of the genetic relationship of iranian h9n2 viruses and other asian viruses. materials and methods: the nucleoprotein (np) genes from 4 isolates of h9n2 viruses isolated from commercial chickens in iran during 2008-2009 were amplified by rt-pcr method and sequenced. nucleotid...

Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae), is one of the most important pest of vegetable and fruit crops. This polyphagous pest has a range of natural enemies including the parasitoid Eretmocerus mundus (Merect) (Hymenoptera: Aphelinidae). To determine the molecular profile and taxonomic status of Iranian isolates of E. mundus, parasitized B. tabaci samples were collected from cotton...