venom with serum and platelets resulted in a progressive increase in coagulant activity. Peden & Peacock (1958) found that ox serum was particularly active in potentiating the coagulant activity of the venom, and suggested that the venom acted enzymically on a substrate contained in the serum. The serum factor can be partially purified by adsorption on barium sulphate and elution by 0-2m-citrat...

The studies on the morphology of lesions produced and the blood coagulation disturbances after Russell viper envenomation were studied in guinea pigs. The study showed very little morphological changes but the coagulation studies revealed disturbances in coagulation mechanism. The exact pathological process operating in Russell viper emvenomation needs further studies including the histochemica...

OBJECTIVES Bee venom (BV) is a complex mixture of proteins and contains proteins such as phospholipase and melittin, which have an effect on blood clotting and blood clots. The mechanism of action of honey bee venom (HBV, Apis mellifera) on human plasma proteins and its anti-thrombotic effect were studied. The purpose of this study was to investigate the anti-coagulation effect of BV and its ef...

introduction: iranian scorpion species are classified in buthidae and scorpionidae with 16 genera and 25 species. in iran, similar to other parts of the world, there are a few known species of scorpions responsible for severe envenoming. mesobuthus eupeus is the most common species in iran. its venom contains several toxin fractions which can affect the ion channel. in this study purification, ...

BACKGROUND During the recent years, significant progress has been achieved on development of novel anti-viral drugs. Natural products are assumed as the potential sources of novel anti-viral drugs; therefore, there are some previous studies reporting the anti-viral compounds from venomous animals. Based on the significant value for tracing of non-toxic anti-viral agents from natural resources, ...

The venom of animals, including snakes, scorpions, and spiders is a complex combination of proteins, peptides, and other biomolecules as well as some minerals. Among the biomolecules of some animal’s venom, small peptides that lack disulfide bands known as Non-Disulfide Bridge Peptides (NDBPs) potentiate the bradykinin by preventing the conversion of angiotensin 1 to angiotensin 2 using the mec...

Agkistrodon halys is one of several dangerous snake species in Iran. Among the most important signs and symptoms in patients envenomated by this snake is disseminated intravascular coagulation. A thrombin-like enzyme, called AH143, was isolated from Agkistrodon halys venom by gel filtration on a Sephadex G-50 column, ion-exchange chromatography on a DEAE-Sepharose and high performance liquid ch...