RESEARCH DESIGN AND METHODS—The Irbesartan in Patients With Type 2 Diabetes and Microalbuminuria (IRMA 2) study was a 2-year multicenter randomized doubleblind trial comparing irbesartan (150 and 300 mg once daily) with placebo. We studied a subgroup of 50 patients where urine samples were available for analysis of albumin and the oxidatively modified guanine nucleosides 8-oxo-7,8-dihydro-29-de...

ALASKA DIVISION Gunter E. Weller Irma Duncan President Executive Secretary PHYSICS (B) CHEMISTRI Edwin M. McMillan Thomas E. RoIf M. Sinclair Leo Schube SOCIAL AND ECONOMIC SCIENCES (K) Robert K. Marton Harvey Sapolsky EDUCATION (Q) DENTISTR Gordon Swanson Martin C Phillip R. Fordyce Sholom F PACIFIC DIVISION John 0. Isaacs Robert T. Orr President Secretary-Treasurer Y(C) .Taylor "I RICHARDH BO...

Our hearts go out to our Gulf and Atlantic Coast neighbors who were battered by the harrowing effects and destructive aftermath of hurricanes Harvey and Irma, which made landfall with historically destructive force in late August and early September. The estimated cost to rebuild and recover is staggering. These disasters will change the infrastructure of nearly all aspects of how Gulf and Atla...

BACKGROUND Chronic airway diseases are often associated with marked mucus production, however, little is known about the regulation of secretory activity by locally released endogenous mediators. AIM This investigation was performed to determine the release of MUC5AC mucin from human bronchial preparations using the purinergic agonists adenosine 5'-triphosphate (ATP) and uridine 5'-triphospha...

The marsupial genus Macropus includes three subgenera, the familiar large grazing kangaroos and wallaroos of M. (Macropus) and M. (Osphranter), as well as the smaller mixed grazing/browsing wallabies of M. (Notamacropus). A recent study of five concatenated nuclear genes recommended subsuming the predominantly browsing Wallabia bicolor (swamp wallaby) into Macropus. To further examine this prop...

The medical automatic annotation task issued by the cross language evaluation forum (CLEF) aims at a fair comparison of state-of-the art algorithms for medical content-based image retrieval (CBIR). The contribution of this work is twofold: at first, a logical decomposition of the CBIR task is presented, and key elements to support the relevant steps are identified: (i) implementation of algorit...

Adrenomedullin (AM) is a potent hypotensive peptide. Plasma contains mature-type AM (m-AM), which is amidated at the carboxy terminus, and an intermediate, AM-Gly. We developed a one-step two-site IRMA specific for determining human m-AM with monoclonal antibodies. The detection limit was 0.5 pmol/L, and the working range (CV <15%) was 1-300 pmol/L. Dilution of plasma samples showed good linear...

H ellemons et al. (1) in a post hoc analysis of the Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria (IRMA)-2 trial provocatively showed that the initial reduction of microalbumiuria with an angiotensin receptor blocker (ARB) was independently associated with renoprotection (i.e., independent of blood pressure changes). Antihypertensive medication was removed for a 3-week run-in...

Human choriogonadotropin (hCG) and free hCG-beta values for 934 serum samples from patients with seminomatous or nonseminomatous testicular cancer were measured by highly specific immunoradiometric assays (IRMAS). In non-seminoma samples, hCG and hCG-beta were highly correlated (r = 0.82, P less than 0.001). Of 112 "marker-positive" seminoma samples, only 46 (41.1%) showed both increased hCG an...

Serum hepatitis B virus (HBV) markers are the most important data for epidemiological screening and clinical diagnosis of HBV infection, especially in endemic areas. We compared the results of the Roche Modular Analytics E170 assay, the Abbott Architect i2000 assay, and an immunoradiometric assay (IRMA) for HBV surface antigen (HBsAg), anti-HBV surface antigen (anti-HBs), HBV e antigen (HBeAg),...