The age-associated decrease in functionality of the human immune system is thought to have a negative impact on the capacity to provide protection against infection, in turn leading to increased incidence of mortality. In a previous longitudinal study of octogenarians, we identified an immune risk phenotype (IRP) in the very elderly defined by an inverted CD4/CD8 ratio, which was associated wit...

As an essential nutrient and a potential toxin, iron poses an exquisite regulatory problem in biology and medicine. At the cellular level, the basic molecular framework for the regulation of iron uptake, storage, and utilization has been defined. Two cytoplasmic RNA-binding proteins, iron-regulatory protein-1 (IRP-1) and IRP-2, respond to changes in cellular iron availability and coordinate the...

In this paper we develop a methodology to estimate the interrelationships of economic growth, increases in income transfe~s, and reduction of poverty over the past fifteen years. The basic question we wish to address is the importance of increases in market incomes relative to income transfers in reducing poverty. Models previously used to project poverty rates have not been specified in such a...

This paper examines implications drawn from labor supply literature for the design of a transfer program for female-headed families when the youngest child turns six years old. It is found that if the average level of support to households remains cons tant, a "safety-net" view of the system would lead to raising the tax rate dramatically while only moderately increasing the guarantee. In contr...

Integrated resource planning (IRP) is a new way for utilities and state regulatory commissions to consistently assess a variety of demand and supply resources to cost-effectively meet customer energy-service needs. This paper reviews recent progress in IRP and identifies the need for additional work by utilities, regulatory commissions, and other organizations. Kevwords: demand-side management,...

In this study, paraphenylenediamine was first bonded to the fullerene and was optimized geometrically by Using the quantum chemistry methods. paraphenylenediamine was examined in the isolated state and in the fullerene-bonded state via carbon atoms. In the theoretical research, the simulation was done by the Gauss View software. Then, the bonding orbital calculation was done by using the NBO me...

The antitumor activity of pristine C60 fullerene aqueous solution (C60FAS) compared to 5-fluorouracil (5-FU) and pyrrole derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2.5-dione (MI-1) cytostatic drugs was investigated and analyzed in detail using the model of colorectal cancer induced by 1.2-dimethylhydrazine (DMH) in rats. The number, size, and location of the tumors were measur...

This paper analyses the acoustic behaviour of Palace Charles V from a room acoustics perspective but also ponders uniqueness space and its ability to engage enhance audience experience. The is relevant part historical heritage Granada. It has an architectural that deserves research. A measurement campaign was made calculate parameters such as T30, IACC, C80 or Gm, explain Palace. BQI quite high...

A modified commercial (Setaram C80) calorimeter has been used to measure the isobaric volumetric heat capacities of concentrated alkaline sodium aluminate solutions at ionic strengths from (1 to 6) mol kg, with up

a fullerene graph is a 3−connected planar graph whose faces are pentagons and hexagons.the clar number of a fullerene is the maximum size of sextet patterns, the sets of disjointhexagons which are all m-alternating for a kekulé structure m of f. an exact formula of clarnumber of some fullerene graphs and a class of carbon nanocones are obtained in this paper.