Insulin signaling is coordinated by insulin receptor substrates (IRSs). Many insulin responses, especially for blood glucose metabolism, are mediated primarily through Irs-1 and Irs-2. Irs-1 knockout mice show growth retardation and insulin signaling defects, which can be compensated by other IRSs in vivo; however, the underlying mechanism is not clear. Here, we presented an Irs-1 truncated mut...

In the present study we have investigated the contribution of the insulin receptor substrate proteins (IRS-1 and IRS-2) to the insulin/insulin like growth factor I (IGF-I)-signaling pathways in fetal rat brown adipocytes, a model that expresses both insulin and IGF-I receptors. Insulin/IGF-I rapidly stimulated IRS-1 and IRS-2 tyrosine phosphorylation, their association with p85alpha, and IRS-1-...

Insulin-like growth factor I (IGF-I) potently stimulates intestinal growth. Insulin receptor substrate-1 (IRS-1) mediates proliferative and antiapoptotic actions of IGF-I in cell lines, but its in vivo relevance in intestine is not defined. This study tested the hypothesis that there is cell type-specific dependence on IRS-1 as a mediator of IGF-I action. Length, mass, crypt cell proliferation,...

We and others recently generated mice with a targeted disruption of the insulin receptor substrate 1 (IRS-1) gene and demonstrated that they exhibited growth retardation and had resistance to the glucose-lowering effect of insulin. Insulin initiates its biological effects by activating at least two major signalling pathways, one involving phosphatidylinositol 3-kinase (PI3-kinase) and the other...

Groundwater quality in Hyderabad has special significance and needs great attention of all concerned since it is the major alternate source of domestic, industrial and drinking water supply. The present study monitors the ground water quality, relates it to the land use / land cover and maps such quality using Remote sensing and GIS techniques for a part of Hyderabad metropolis. Thematic maps f...

The topographical characteristic features of a land surface landforms, elevation, rocks, soils, and vegetation. The study was undertaken to prepare an inventory of terrain characteristics. The study area is North latitudes 17d27’00”: 18d18’00”and East longitudes 77d 28’00” and is included in Survey of India toposheets 56G6, 56G10, 56G13, 56G14, 56G15, 56K02, 56K03, 56K06, and 56K07). The IRS-ID...

This study focuses on the analysis of the Landsat-5 TM + SPOT-Pan (1992), IRS-1C/D LISS + Pan (2000), and Landsat-5 TM (2006) satellite images that reflect the drastic land use/land cover changes in the Küçükçekmece Lake region, Istanbul. Landsat-5 TM satellite data dated 2006 was used for mapping water quality. A multiple regression analysis was carried out between the unitless planetary refle...

Multiresolution segmentation is a new procedure for image object extraction. It allows the segmentation of an image into a network of homogeneous image regions at any chosen resolution. These image objects represent image information in an abstracted form and serve as building blocks for subsequent classifications. An exercise was undertaken to perform and study an object oriented segmentation ...

The concentration of people in densely populated urban areas, especially in developing countries, calls for the use of monitoring systems like remote sensing. Such systems along with spatial analysis techniques like digital image processing and geographical information system (GIS) can be used for the monitoring and planning purposes as these enable the reporting of overall sprawl at a detailed...

Dry land farming in India accounts for 63% of the cultivated land of 144 million hectares. The crop production on these lands is dependent entirely on the natural precipitation, which is highly erratic in terms of spatial and temporal distribution during the crop-growing season. To address these problems, Government of India has accorded high priority to watershed approach for development of ra...