Currently, there is no specific antiviral therapy for treatment of HPV infection. Jiang and colleagues previously reported that anhydride-modified proteins have inhibitory activities against multiple viruses including HPV. Here, we evaluated the safety of 3-hydroxyphthalic anhydride-modified bovine beta-lactoglobulin, designated JB01, vaginally applied in women infected by high-risk HPV. After ...

the same. Only a small amount of non-metabolized EPTC remained. With only minor differences in the EPTC metabolism patterns of the anhydride-treated and non-treated corn, it would be difficult to explain the anhydride's action on the basis of EPTC metabolism alterations. From these results, it is clear that the mode of action of the 1,8-naphthalic anhydride is not that of a simple interference ...

Ab initio molecular dynamics (MD) simulations were employed to elucidate xylose and glucose degradation pathways. In the case of xylose, a 2,5-anhydride intermediate was observed leading to the formation of furfural through elimination of water. This pathway agrees with one of the mechanisms proposed in the literature in that no open chain intermediates were found. In the case of glucose, a ser...

A preliminary experimental study was carried out to examine the ability of a chemically modified Acacia spp. to resist biodegradation. The modifications of Acacia mangium and Acacia hybrid were carried out by propionic anhydride and succinic anhydride in the presence of sodium formate as a catalyst. The treated samples were found resistant to microbial attack, while the untreated ones were dama...

The first reported hybrid artificial neural network-genetic algorithm (ANN-GA) approach for the optimization of on-capillary dipeptide derivatization is presented. More specifically, genetic optimization proved valuable in the determination of effective network structure with three defined parameter inputs: (i) phthalic anhydride injection volume, (ii) time of injection, and (iii) voltage, for ...

The cationic ring-opening polymerization reaction of tetrahydrofuran at 20 degrees C was catalyzed by H3PW12O40 x 13 H2O as solid acid catalyst. The effect of the proportions of acetic anhydride and catalyst, reaction time and support on the polymerization reaction was investigated. It has been found that the yield and the viscosity of the polymer depend on the proportion of acetic anhydride, t...

Direct benzoylation of the two hydroxyl groups on chitosan was achieved using a phosphoryl mixed anhydride system, derived from trifluoroacetic anhydride (TFAA), benzoic acids (BAs), and phosphoric acid (PA). The reaction is operated as a one pot process under mild conditions that does not require neither an inert atmosphere nor dry solvents. The structures of the synthesized compounds were con...