The effects of PAR2-activating PAR2-activating peptides, SLIGRL (SL)-NH2, and trans-cinnamoyl-LIGRLO (tc)-NH2 were compared with the action of trypsin, thrombin, and the PAR1 selective-activating peptide: Ala-parafluoroPhe-Arg-cyclohexylAla-Citrulline-Tyr (Cit)-NH2 for stimulating intestinal ion transport. These agonists were added to the serosa of stripped rat jejunum segments mounted in Ussin...

Recent identification of intestinal epithelial stem cell (ISC) markers and development of ISC reporter mice permit visualization and isolation of regenerating ISCs after radiation to define their functional and molecular phenotypes. Previous studies in uninjured intestine of Sox9-EGFP reporter mice demonstrate that ISCs express low levels of Sox9-EGFP (Sox9-EGFP Low), whereas enteroendocrine ce...

BACKGROUND/AIMS We have previously shown that daily subcutaneous injections with the naturally occurring phytoestrogen genistein (600 mg genistein/kg body weight/day, 600G) results in a significantly increased basal intestinal chloride, Cl(-), secretion (Isc, a measure of transepithelial secretion) in intact C57BL/6J female mice after 1-week of treatment, compared to controls (DMSO vehicle inje...

PURPOSE To study the feasibility/toxicity of urethral stenting with the Memokath® 028SW stent in patients undergoing prostate implant (PI) for prostate adenocarcinoma. MATERIAL AND METHODS An Investigational Device Exemption from the Food and Drug Administration (FDA) and institutional review board (IRB) approval were obtained. Twenty patients enrolled. Baseline American Urological Associatio...

Urinary retention is a common problem for women following surgery, and a significant complication for those who have undergone urogynaecologic surgery, with prevalence estimated between 2.5% and 24% (Dorflinger and Monga, 2001). Postoperative urinary retention (POUR) can lead to bladder distention, causing altered bladder function, urinary tract infections and poor surgical outcomes. Intermitte...

This report reflects on the presentations given during ISC 2015 with an emphasis on the topics of my personal interest. Attendance of the even was funded by COINS Research School.

The amount of oil together with the water Originally in Place (OIP), makes up liquid phase heavy reservoir systems. This present pores system is known as saturation, plays a vital role improving recovery through In-Situ Combustion (ISC) process. acts fuel generating thermal energy required for viscosity reduction and supports formation an enlarged condensation zone that aids higher mobility low...

PURPOSE Mutations in BEST1, encoding Bestrophin-1 (Best1), cause Best vitelliform macular dystrophy (BVMD) and other inherited retinal degenerative diseases. Best1 is an integral membrane protein localized to the basolateral plasma membrane of the retinal pigment epithelium (RPE). Data from numerous in vitro and in vivo models have demonstrated that Best1 regulates intracellular Ca2+ levels. Al...

This paper reports on a new computational methodology, inter-slice correspondence (ISC), for robustly aligning sets of 2D ultrasound (US) slices during image-guided medical procedures. Correspondences are derived from distinctive, local scale-invariant features, which are used in one-to-many matching of US slices in near real-time despite out-of-plane rotation, in addition to global in-plane si...

Mutations and deletions in the mitochondrial genome (mtDNA), as well as instability of the nuclear genome, are involved in multiple human diseases. Here, we report that in Saccharomyces cerevisiae, loss of mtDNA leads to nuclear genome instability, through a process of cell-cycle arrest and selection we define as a cellular crisis. This crisis is not mediated by the absence of respiration, but ...