OBJECTIVE Despite cerebral ischemia being a frequent clinical pathologic state, the tolerance of neural tissue to oxygen absence and to reperfusion is controversial. This study aims to evaluate the effects of focal cerebral ischemia/reperfusion, by analyzing the mitochondrial respiration. METHOD Sixty-four adult rats underwent focal cerebral ischemia by middle cerebral artery occlusion, durin...

Objective: It is generally agreed that most of the phenomena observed during brain ischemia and reperfusion can be explained by the damage to membrane structure. Oxidative stress is resulted in an imbalance between high consumption of oxygen and low levels of endogenous antioxidants. It is known that gallic acid (GA) is a strong antioxidant. The present study was carried out to evaluate the eff...

objective: oxidative stress damages cells and brings about the pathogenesis of ischemia/reperfusion injury. this study was carried out to investigate the preconditioning and cardio protective potential effects of crocin and vitamin e by the enos and inos express gene in ischemia/reperfusion in rats. material & methods: male rats were divided into seven groups, namely: sham, control group and ex...

Purpose: Ischemia-reperfusion (I/R) injury exacerbates myocardial cell death (including apoptosis and necrosis), leading to complications such as arrhythmias, stenosis, microvascular obstruction heart failure, it is particularly important seek new strategies mitigate reperfusion injury. In this paper, we will investigate whether atorvastatin can alleviate ischemia-reperfusion verify its molecul...

Background: This study was aimed to investigate the hepatoprotective effect of RSV against oxidative stress damage which we induced an experimental liver Ischemia-reperfusion (I/R) model in rats. Methods: Female albino rats were divided into three groups (n = 8). Contrast control group, 1 ml saline (0.09 % NaCl) administered intraperitoneally two days before operation and after reperfusion sham...

PURPOSE To investigate the effects of ischemic preconditioning (IPC) on the expression of pro and anti-apoptotic genes in rat endothelial cells undergoing enteric ischemia (I) and reperfusion (R). METHODS Thirty rats underwent clamping of the superior mesenteric vessels. Sham group (GS) laparotomy only; Ischemia (GI): intestinal ischemia (60 min); Ischemia and Reperfusion (GIR): ischemia (60 ...

objective(s):this study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. materials and methods: male wistar rats were anesthetized by thiopental sodium (50 mg/kg, ip) followed by iv injection of heparin (250 iu). remote ischemic preconditioning (ripc) was induce...

objective(s):this study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (i/r) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. it also examined the effects of the drugs aimed at preventing infertility that may result from i/r injury. materials and methods: diabetic rats were divided into ...

Evaluating the impact of Viola spathulata in a rat model brain ischemia/reperfusion by influencing expression level caspase-3 and cyclooxygenase-2

Introduction: The aim of this study was to investigate the effect of angiotensin II (Ang II) and losartan injections into paraventricular nucleus (PVN) on renal ischemia-reperfusion injury. Methods: After right nephrectomy in male rats, a cannula was inserted into the right PVN. One week later, renal ischemia-reperfusion (IR) injury was induced by clamping the left renal artery for 45 min, a...