objective(s):acute kidney injury (aki), a syndrome characterized by decreased glomerular filtration, occurs in every 1 of 5 hospitalized patients.  renal ischemia-reperfusion, one of the main causes of aki, is of particular importance in the setting of kidney transplantation. materials and methods: sixty male rats were divided into four groups including control, nephrectomy, sham surgery and re...

background: renal ischemia reperfusion injury may occur in a variety of clinical situations, following a transient drop in total or regional blood flow to the kidney. this study was performed to investigate the protective effects of different antioxidants such as vitamin c, vitamin e, hydrocortisone and combination of these agents against experimental renal ischemia-reperfusion injury. method:...

Objectives: Ischemia/reperfusion (I/R) injury is commonly seen in cardiovascular surgery, activates inflammation and causes renal damage. In this experimental study, we aimed to assess the effects of different doses (5 30 mg/kg) methylprednisolone (MP), which has anti-inflammatory effect, on ischemia/reperfusion injury. Methods: Thirty-two male Wistar albino rats were randomly divided into four...

Objective(s): According to recent the findings, sulfur dioxide (SO2) is produced by the cardiovascular system, influencing some major biological processes. Based on previous research, SO2 exhibits antioxidant effects and inhibits apoptosis following cardiac ischemia/reperfusion. Therefore, the objective of the current study was to examine the neuroprotective impact of SO2 following global cereb...

0

background & target: ischemia reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. in this study, the effect of pentoxyfylline on bcl2 gene expression changes and cell injury in kidney of rat following ischemia reperfusion were evaluated.methods: in this experimental study, 20 male wistar rats with average weight of...

Abstract Background Primary graft dysfunction (PGD) remains a major obstacle after lung transplantation. Ischemia–reperfusion injury is known contributor to the development of PGD following We developed novel approach assess impact increased pulmonary blood flow in large porcine single-left transplantation model. Materials Twelve left transplants were divided two groups ( n = 6, low- (LF) and h...

Redox balance maintaining is a prerequisite for normal cardiomyocytes metabolism. Reperfusion injury of the heart characterized by an explosive increase in ROS generation, cell membranes damage, dysfunction proteins, development muscle contracture etc. It was shown that hydrogen sulfide (H2S) and precursor its synthesis amino acid L-cysteine provided cardioprotective effect against ischemiarepe...