objective(s):global cerebral ischemia-reperfusion injury causes loss of pyramidal cells in ca1 region of hippocampus. in this study, we investigated the possible neuroprotective effects of the ethanol extract of cyperus rotundus (eecr) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and spatial memory. materials and methods: treatment ...

Objective(s):Global cerebral ischemia-reperfusion injury causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the possible neuroprotective effects of the ethanol extract of Cyperus rotundus (EECR) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and spatial memory. Materials and Methods: Treatment ...

The brain requires O2 and nutrition to keep functioning. It is known that concentration converts the polarity of vessel response near activated neuron in hippocampus. However, it remains unclear whether cortex. We investigated comparison arteriole stimulated neurons cerebral cortex slices between 95% 20% medium. showed diameter blood vessels decreased under when pyramidal cells were increased w...

Proechimys (Rodentia: Echimyidae) is a neotropical rodent of the Amazon region that has been successfully colonized in the laboratory and used for experimental medicine. Preliminary studies indicated that Proechimys (casiragua) rodents express an atypical resistance to developing a chronic epileptic condition in common models of temporal lobe epilepsy. Moreover, previous investigation of our la...

Fifteen years ago, a research report claiming that brain injury stimulates production of new neurons in postnatal mammalian forebrain would have been met with widespread skepticism. Since then, considerable experimental evidence has emerged indicating that neural stem cells and neurogenesis persist in specific regions of the neonatal and adult mammalian forebrain (reviewed in Ming and Song). Ma...

Formation of new recurrent excitatory circuits after brain injuries has been hypothesized as a major factor contributing to epileptogenesis. Increases in total axonal length and the density of synaptic boutons are present in layer V pyramidal neurons of chronic partial isolations of rat neocortex, a model of posttraumatic epileptogenesis. To explore the functional consequences of these changes,...

Dendritic spines form postsynaptic components of excitatory synapses in CA1 pyramidal neurons and play a key role in excitatory signal transmission. Transient global ischemia is thought to induce excitotoxicity that triggers delayed neuronal death in the CA1 region. However, the mechanism underlying structural changes of excitatory synapses after ischemia is not completely understood. Here, we ...

During cortical development, synaptic competition regulates the formation and adjustment of neuronal connectivity. It is unknown whether synaptic competition remains active in the adult brain and how inhibitory neurons participate in this process. Using morphological and electrophysiological measurements, we show that expressing a dominant-negative form of the TrkB receptor (TrkB.T1) in the maj...

In mice, genetically engineered knockout of the Dapper Antagonist of Catenin-1 (Dact1) locus, which encodes a scaffold protein involved in Wnt signaling, leads to decreased excitatory input formation on dendrites of developing forebrain neurons. We have previously demonstrated this in both (excitatory, glutamatergic) pyramidal neurons of the hippocampus and in (inhibitory GABAergic) interneuron...