Background and Purpose—Hemorrhagic transformation is frequently seen on CT scans obtained in the subacute phase of ischemic stroke. Its prognostic value is controversial. Methods—We analyzed 554 patients with acute ischemic stroke enrolled in the Multicenter Acute Stroke Trial–Italy (MAST-I) study in whom a second CT scan was performed on day 5. Presence of 1) intraparenchymal hemorrhages (hema...

BACKGROUND AND PURPOSE The relevance of elevated blood pressure in acute ischemic stroke and its most appropriate management are unresolved. We aimed to evaluate the rate of functional recovery with relation to early blood pressure management in patients with ischemic stroke. METHODS Four hundred eighty-one consecutive ischemic stroke patients were admitted to the Neurology Service within 20....

A small percentage of patients who suffer a global cerebral hypoxic/ischemic event develop reversal of the normal density relationships of gray and white matter on CT. CT and pathologic findings in the three cases presented indicate that this phenomenon appears to result from distension of deep medullary veins secondary to partial obstruction of venous outflow from elevated intracranial pressur...

Brain Injury Mechanisms of Brain Injury Hypoxia and Ischemia Excitatory Amino Acid Injury Cerebral Edema Increased Intracranial Volume and Pressure Brain Herniation Hydrocephalus Traumatic Head and Brain Injury Skull Fractures Traumatic Brain Injury Manifestations of Global Brain Injury Anatomic and Physiologic Basis of Consciousness Reticular Activating System Levels of Consciousness Other Man...

OBJECTIVE To determine whether the use of contrast enhancement (especially its extent) predicts malignant brain edema after intra-arterial thrombectomy (IAT) in patients with acute ischemic stroke. METHODS We reviewed the records of patients with acute ischemic stroke who underwent IAT for occlusion of the internal carotid artery or the middle cerebral artery between January 2012 and March 20...

Blood-brain barrier (BBB) Na transporters are essential for brain water and electrolyte homeostasis. However, they also contribute to edema formation during the early hours of ischemic stroke by increased transport of Na from blood into brain across an intact BBB. We previously showed that a luminal BBB Na-K-Cl cotransporter is stimulated by hypoxia, aglycemia, and AVP and that inhibition of th...