BACKGROUND ECG left ventricular hypertrophy (LVH) is a well-known predictor of cardiovascular disease. However, no prior study has characterized patterns of presence/absence of ECG LVH ("ECG LVH trajectories") across the adult lifespan in both sexes and across ethnicities. We examined: (1) correlates of ECG LVH trajectories; (2) the association of ECG LVH trajectories with incident coronary hea...

background: clopidogrel is one of the most commonly prescribed drugs to prevent ischemic events following coronary syndromes or stent placement. however, impaired responses to therapy as well as resistance are also reported. genetic variants play an important role in clopidogrel biotransformation to its active metabolite that may subsequently influence the clopidogrel antiplatelet effect. the o...

conclusions the prevalence of undiagnosed ihd in the hd patients was considerable. we, therefore, suggest that ihd be assessed in hd patients, especially those at high risk due to positive family history of cad, hypertension, left ventricular hypertrophy, diabetes mellitus, kt/v < 1.2, low ferritin levels, and high levels of intact parathyroid hormone. results sixty-nine hd patients were studie...

Methods ICELAND-MI is a nested cohort of the Age, Gene/ Environment Susceptibility-Reykjavik Study of community-dwelling older adults that intentionally oversampled diabetic subjects. After excluding subjects with pre-existing heart failure, the cohort size was 900. CMR was used to detect myocardial infarction (MI), major patterns of non-ischemic patterns of LGE as defined by Vöhringer (Herz 20...

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In recent decades, cardiac magnetic resonance imaging (CMR) has been established &amp;nbsp;as a valuable tool in the diagnosis of patients with or at risk heart failure. With its ability to characterize tissue changes myocardium, CMR can provide detailed and clinically useful information about type severity damage. The method is not only important for differentiation ischemic from non-ischemic ...

Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency are not represented in clinical trials for heart failure. Moreover, many of the recommended medications can cause haemolysis this group patients. We present case a 71-year-old woman G6PD admitted acute non-ischemic failure reduced ejection fraction. Our experience showed that combination ethacrynic acid and spironolactone is safe...

OBJECTIVES Plasma endothelin (ET) concentrations are increased in heart failure. The aims of the present study were to investigate to what extent cardiac ET mRNA expression is induced in ischemic heart failure and whether there may be compensatory downregulation of myocardial mRNA levels for the ETA and ETB receptor subtypes. METHODS In rats with ischemic heart failure (left ventricular end-d...

Abdominal aortic aneurysm (AAA) is very frequently accompanied by coronary artery disease. Myocardial ischemia is the leading cause of mortality and morbidity in AAA repair. Therapeutic strategy, in presence of ischemic heart failure and AAA, is not well established. Actually, AAA is considered as a contraindication to ventricular assist device (VAD) support. We report a unique case of concomit...

BACKGROUND Heart failure results from abnormalities in multiple biological processes that contribute to cardiac dysfunction. We tested the hypothesis that inherited variation in genes of known importance to cardiovascular biology would thus contribute to heart failure risk. METHODS AND RESULTS We used the ITMAT/Broad/CARe cardiovascular single-nucleotide polymorphism array to screen referral ...