Novel derivatives of puberulic acid were synthesized and their antimalarial properties evaluated in vitro against the Plasmodium falciparum K1 parasite strain, cytotoxicity a human diploid embryonic cell line MRC-5, vivo efficacy using berghei-infected mouse model. From previous information that three hydroxy groups on tropone framework essential for activity, we converted carboxylic moiety int...

patients and methods we evaluated radiation exposure from initial and downstream testing in a prospectively collected, matched cohort evaluated for cp in the emergency department (ed) with either ccta compared with usual care over a median follow-up of 19.6 months. effective radiation dose was calculated using published conversion factors. results prospective, ecg-triggered acquisition using a ...

introduction: to measure radiation exposures rate in low-risk patients having stress-only and stress-rest myocardial perfusion imaging. methods: this was a prospective study conducted from january 2012 till november 2012 upon patients with low pre-test probability for coronary artery disease (cad). a stress mpi (stress-only if mpi is normal and no resting study) followed by a resting mpi study...

introduction the exposure of human beings to ionizing radiation from natural sources is a continuing and inescapable feature of life on earth. for most individuals, this exposure exceeds that from all man-made sources combined. materials and methods in this study, the annual effective dose in high level environmental background radiation areas (hlebras) of northern city of ramsar in iran was de...

Objectives Scutellarin (Scu) is the main effective constituent of Erigeron breviscapus which has anti-oxidant, anti-apoptotic, anti-inflammatory and other therapeutic properties. The purpose of this study was to investigate the protective effect of Scu on myocardial infarction (MI) induced by isoprenaline (ISO). Materials and Methods The rats were subcutaneously injected with ISO (45 mg/kg) o...

Different human-like cardiomyopathies associated to β-adrenergic stimulation are experimentally modeled in animals through variations in dose, route, and duration of administration of different cardiotoxic drugs. However, associated changes in the vasculature and their relation to systemic inflammation, and the influence of cardiovascular diseases risk factors (gender and age) upon them are sel...

The aim of the present study was to determine the optimal dose and optimal target volume for marginal zone lymphoma of the ocular adnexa. Between January, 2008 and December, 2013, 40 patients with histologically proven primary marginal zone lymphoma of the ocular adnexa who underwent radiotherapy at the Tokyo Medical University were evaluated. The prescribed dose was 30 Gy in 15 fractions to th...

The development of lower-glycaemic index (GI) foods requires simple, palatable and healthy strategies. The objective of the present study was to determine the most effective dose of a novel viscous fibre supplement (PGX®) to be added to starchy foods to reduce their GI. Healthy subjects (n 10) consumed glucose sugar (50 g in water × 3) and six starchy foods with a range of GI values (52-72) alo...