We present new results from a continuing Keck program to study gravitational lens systems. We have obtained redshifts for three lens systems, SBS 0909+532, HST 1411+5211, and CLASS B2319+051. For all of these systems, either the source or lens redshift (or both) has been previously unidentified. Our observations provide some of these missing redshifts. We find (z ℓ , z s) = (0.830, 1.377) for S...

The generation of genome-modified animals is a powerful approach to analyze gene functions. The CAS9/guide RNA (gRNA) system is expected to become widely used for the efficient generation of genome-modified animals, but detailed studies on optimum conditions and availability are limited. In the present study, we attempted to generate large-scale genome-modified mice with an optimized CAS9/gRNA ...

Benign Pigmented Lesions in Older Adults: A Field Guide Gordon E. Searles, OD, MD, MSc, FRCPC, FACP, Internal Medicine and Dermatology, Western Canada Dermatology Institute, Edmonton, AB. SKIN DISORDERS

Software architects use a number of commonly-recognized “styles” to guide their design of system structures. Each of these is appropriate for some classes of problems, but none is suitable for all problems. How, then, does a software designer choose an architecture suitable for the problem at hand? Two kinds of information are required: (1) careful discrimination among the candidate architectur...