نتایج جستجو برای: isomerization analysis

تعداد نتایج: 2829060  

Journal: :Canadian Journal of Chemistry 1966

Journal: :Biochemical Journal 1939

Journal: :YAKUGAKU ZASSHI 1960

Journal: :The Journal of chemical physics 2005
Jasper R Clarkson Esteban Baquero Timothy S Zwier

The methods of stimulated emission pumping-hole-filling spectroscopy (SEP-HFS) and population transfer spectroscopy (SEP-PTS) were used to place direct experimental bounds on the energetic barriers to conformational isomerization in 3-indole-propionic acid (IPA) and its water-containing complex. By contrast with tryptamine (Paper I), IPA has only two conformations with significant population in...

Journal: :Biochemistry 1996
J P Schanstra I S Ridder G J Heimeriks R Rink G J Poelarends K H Kalk B W Dijkstra D B Janssen

Conversion of halogenated aliphatics by haloalkane dehalogenase proceeds via the formation of a covalent alkyl-enzyme intermediate which is subsequently hydrolyzed by water. In the wild type enzyme, the slowest step for both 1,2-dichloroethane and 1,2-dibromoethane conversion is a unimolecular enzyme isomerization preceding rapid halide dissociation. Phenylalanine 172 is located in a helix-loop...

2011
Lifeng Yang Jing Zhang Bow Ho Jeak Ling Ding

BACKGROUND M-ficolin, a pathogen recognition molecule in the innate immune system, binds sugar residues including N-acetyl-D-glucosamine (GlcNAc), which is displayed on invading microbes and on apoptotic cells. The cis and trans Asp282-Cys283 peptide bond in the M-ficolin, which was found to occur at neutral and acidic pH in crystal structures, has been suggested to represent binding and non-bi...

Journal: :Neuron 2009
Sangwoo Shim Joseph P. Yuan Ju Young Kim Weizhong Zeng Guo Huang Aleksandr Milshteyn Dorothee Kern Shmuel Muallem Guo-li Ming Paul F. Worley

Immunophilins, including FK506-binding proteins (FKBPs), are protein chaperones with peptidyl-prolyl isomerase (PPIase) activity. Initially identified as pharmacological receptors for immunosuppressants to regulate immune responses via isomerase-independent mechanisms, FKBPs are most highly expressed in the nervous system, where their physiological function as isomerases remains unknown. We dem...

2013
Neeraj Rai Stavros Caratzoulas Dionisios G. Vlachos

Density functional calculations are used to elucidate the role of the silanol group adjacent to the active site Sn metal center of the Sn-BEA zeolite in the isomerization and epimerization of glucose. We find that the silanol group plays an important role in the isomerization reaction, wherein hydride transfer and subsequent proton transfer occur in a single step with a lower energy of activati...

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