In the study presented here, the effect of zinc deficiency on mRNA expression levels in liver and jejunum of adult rats was analyzed. Feed intake was restricted to 8 g/day. The semi-synthetic diet was fortified with pure phytate and contained either 2 microg Zn/g (Zn deficiency, n = 6) or 58 microg Zn/g (control, n = 7). After 29 days of Zn depletion feeding, entire jejunum and liver were retri...

red for evaluation of recurrent episodes of melena. Gastroscopy, colonoscopy with ileoscopy, and small-bowel computed tomography (CT) scanwere normal. Capsule endoscopy (Pill cam SB 2, Given Imaging, Yoqneam, Israel) disclosed a lesion with whitish carpet-like villi and superficial red spots with spontaneous bleeding at the proximal jejunum. At double-balloon enteroscopy (Fujinon, Saitama, Japa...

The purpose of this study was to determine the characteristics of intestinal absorption and metabolism of cimetidine. The initial finding of the appearance of cimetidine sulfoxide in rat and human jejunum from cimetidine perfusions had prompted an isolation of mucosal membrane transport and enterocyte metabolism contributions in earlier membrane vesicle and microsomal studies, respectively. In ...

The effect of the short duration (21 days) of caffeine at two different doses (12 mg & 30 mg/kg body weight/day) on the activities of adenosine triphosphatases in jejunum was studied. The activity of Na+, K+ -dependent ATP-ase was reduced significantly in the upper jejunal mucosal and serosal layers of low an high dose groups. Such effect was observed only in the lower jejunal serosal layer whi...

Sarcomatoid carcinoma of the small intestine is rare, and only 30 cases have been reported to date. This disease generally exhibits a very poor prognosis. Here we report the case of a 67-year-old man with a sarcomatoid carcinoma in the jejunum, who was hospitalized for diarrhea, fever, nausea, and vomiting. The tumor was located at the jejunum and had a large round shape with geographic necrosi...

The Paneth cell population in surgically resected human jejunum and ileum was estimated using image analysis of the granule area in patients who had not received antibiotics. The mucosa was cultured aerobically and anaerobically. In the jejunum 22 samples were sterile and five yielded bacteria; in the ileum four were sterile and three were non-sterile. The mean Paneth cell granule area in the s...

PPAR-α plays a key role in lipid metabolism; it enhances fatty acid oxidation (FAO) and ketogenesis. Pharmacological PPAR-α activation improves insulin sensitivity and reduces food intake, but its mechanisms of action remain unknown. We here report that intraperitoneal (IP) administration of the PPAR-α agonist Wy-14643 (40 mg/kg BW) reduced food intake in adult male rats fed a high-fat diet (HF...

Fluid transport was measured gravimetrically in vivo in the jejunum, ileum and colon of fed, fasting (four days) and undernourished (50 % of control food intake for 21 days) gerbils (Gerbillus cheesmani). The effects of luminal enterotoxin Escherichia coli STa (50 ng/ml) and luminal 8-bromo-cyclic GMP (cGMP 1 mM) on fluid transport across jejunum, ileum and colon were also assessed. Fasting and...

Esworthy, R. Steven, Jeffrey R. Mann, Mindy Sam, and Fong-Fong Chu. Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from g-irradiation damage. Am J Physiol Gastrointest Liver Physiol 279: G426–G436, 2000.—Gpx1 knockout (KO) mice had a higher number of regenerating crypts in the jejunum than did Gpx2-KO or wild-type mice analyzed 4 days after $10 Gy g-irradiatio...

Peptide transporters 1 and 2 (PepT1 and PepT2) and peptide/histidine transporter 1 (PHT1) are all members of the proton-coupled oligopeptide transporter family, which are important for the transport of amino acids in peptide form. The PepT1 acts as a low-affinity/high-capacity transporter and PepT2 as a high-affinity/low-capacity transporter for di- and tri-peptides. The PHT1 transports di- and...