Members of the transforming growth factor-beta family (e.g. TGF-beta, BMP and activin) are critical regulators of tooth morphogenesis. The basic TGF-beta signaling engine consists of a receptor complex that activates Smads and a Smad-containing complex that controls transcription of the downstream target genes. Little is known about the expression of endogenous Smads during tooth morphogenesis....

The first stage of modernizing cultivation the main grain crops lies in exogenous use natural growth regulators and nanofertilisers for pre-sowing seed treatment. Special attention is paid to quality winter wheat material, given high probability germination stressful climatic conditions need form winter-hardy crops. Therewith, this study relevant because modern requirements agronomic biofortifi...

Many signaling proteins and transcription factors that induce and pattern organs have been identified, but relatively few of the downstream effectors that execute morphogenesis programs. Because such morphogenesis genes may function in many organs and developmental processes, mutations in them are expected to be pleiotropic and hence ignored or discarded in most standard genetic screens. Here w...

Background: Small GTPase Rab17 regulates dendritic morphogenesis of hippocampal neurons, but its activation mechanism is completely unknown. Results: Expression of Rabex-5 in mouse hippocampal neurons promoted dendritic localization of Rab17, and Rabex-5 knockdown resulted in inhibition of neurite morphogenesis. Conclusion: Rabex-5 regulates neurite morphogenesis by activating Rab5 and Rab17. S...

We conducted a genetic analysis of the developing temporo-mandibular or temporomandi-bular joint (TMJ), a highly specialized synovial joint that permits movement and function of the mammalian jaw. First, we used laser capture microdissection to perform a genome-wide expression analysis of each of its developing components. The expression patterns of genes identified in this screen were examined...

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 background : strength improvement of the shoulder muscles is a major goal in rehabilitation or athletic conditioning programs. the purpose of this study was to determine the effect of shoulder core exercises on the isometric torque of glenohumeral joint movements. methods : a total of 36 healthy females with no history of sho...

Previous studies have suggested that basement membrane alone may induce ductal differentiation and morphogenesis in the undifferentiated embryonic pancreas. The mechanism by which this induction occurs has not been investigated. Studies of other organ systems such as the lungs and mammary glands, where differentiation has been shown to be induced by basement membrane, have suggested a major rol...

Gene expression controls the cellular differentiation and morphogenesis for body organisation. Every species has different unique patterns this is influenced by certain group of genes called as homeobox genes. Molecular events are involved in tooth development process or odontogenesis also controlled It was first identified fruit fly Drosophila Melanogaster.

Ezrin, a membrane-actin cytoskeleton linker, which participates in epithelial cell morphogenesis, is held inactive in the cytoplasm through an intramolecular interaction. Phosphatidylinositol 4,5-bisphosphate (PIP2) binding and the phosphorylation of threonine 567 (T567) are involved in the activation process that unmasks both membrane and actin binding sites. Here, we demonstrate that ezrin bi...