OBJECTIVE To evaluate the predictive value of tender joints compared to synovitis for structural damage in rheumatoid arthritis (RA). METHODS A post hoc analysis was performed on a prospective 2-year study of 59 patients with active RA starting on antitumour necrosis factor (TNF). Tenderness and synovitis was assessed clinically at baseline, followed by blinded ultrasound assessment (B-mode a...

OBJECTIVES Target joints are a common complication of severe haemophilia. While factor replacement therapy constitutes the majority of costs in haemophilia, the relationship between target joints and non drug-related direct costs (NDDCs) has not been studied. METHODS Data on haemophilia patients without inhibitors was drawn from the 'Cost of Haemophilia across Europe - a Socioeconomic Survey'...

It was impossible to demonstrate a condition of specific joint sensitization to non-hemolytic streptococci by first injecting the joints of rabbits with small doses of killed non-hemolytic streptococci, or with extracts of these organisms, and subsequently inoculating the rabbits intravenously with homologous living bacteria. Joints so treated were no more liable to involvement than were other ...

Technetium labelled, negatively charged, unilamellar liposomes were given by intravenous injection to patients with rheumatoid arthritis and the joints scanned 20-22 hours later. Positive scintigraphy was obtained in all six patients with active disease, and, with the exception of the small interphalangeal joints, all clinically involved joints could be visualised.

● Rheumatoid arthritis (RA) and Juvenile RA (JRA) joints; less commonly lung, skin ● Lupus (Systemic Lupus Erythematosus) skin, joints, kidneys, heart, brain, red blood cells, other ● Scleroderma skin, intestine, less commonly lung ● Sjogren's syndrome salivary glands, tear glands, joints ● Goodpasture's syndrome lungs, kidneys ● Wegener's granulomatosis blood vessels, sinuses, lungs, kidneys ●...

STUDY DESIGN A descriptive in vitro study on isolation and differentiation of human mesenchymal stem cells (MSCs) derived from the facet joints and interspinous ligaments. OBJECTIVE To isolate cells from the facet joints and interspinous ligaments and investigate their surface marker profile and differentiation potentials. SUMMARY OF BACKGROUND DATA Lumbar spinal canal stenosis and ossifica...

The friction coefficients measured in diarthrodial joints are small. Theories of joint lubrication attribute this efficiency to entrapment or movement of synovial fluid, yet anatomical models of the surface are based on studies of isolated fragments of cartilage, not functional joints. To investigate the functional interrelationship of joint surfaces and synovial fluid, the ultrastructure of lo...