Abstract “I am waiting for the day when someone will discover mystery of life's origin … My biggest motivation is excitement making a new observation …” Find out more about Benesh Joseph in his Introducing Profile.

Sister Mary Joseph nodule or Sister Mary Joseph Sign refers to a palpable nodule bulging into the umbilicus as a result of metastasis of a malignant cancer in the pelvis or abdomen. A rare case of Sister Mary Joseph nodule, manifesting as ascites, cachexia and bleeding per rectum, is presented without any primary tumor despite extensive search for the same.

Joseph Leonard Doob was born in Cincinnati, Ohio, USA on 27 February 1910. In an interview Joe gave for Statistical Science (see Snell (1997)), he said that in grammar school he built a crystal set and in high school operated a radio transmitter. This led him to think he would major in mathematical physics when he entered Harvard in 1926. However, after taking two physics courses, Doob decided ...

TO THE EDITOR: Many thanks to Dr. Joseph (1) for requesting clarification of methods used to measure metabolic rate of the rodent in our recent study (3). Measurements of V̇O2 and V̇CO2 in the rat do indeed require a great deal of precision, given that the differences between inspired and expired fractions of O2 and CO2 are very small. Dr. Joseph’s letter highlights some very important potential ...

Joseph Needham [4] was an embryologist and biochemist who is most noted in science for his studies on induction [5] in developing embryos. Needham worked with Conrad Hal Waddington [6] to attempt to identify the compound responsible for the organizer?s activity. Although he was not successful in discovering the chemical, he and Waddington learned much about the organizer [7]. Needham was a meti...