Nuclear factor-kB (NF-kB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. Activation of NF-kB mainly occurs via IkB kinase (IKK)-mediated phosphorylation of inhibitory molecules, including IkBa. Optimal induction of NF-kB target genes also requires phosphorylation of NF-kB proteins, such as p65, within their transactivation domain by...
