A series of enzymes for Kemp elimination of 5-nitrobenzisoxazole has been recently designed and tested. In conjunction with the design process, extensive computational analyses were carried out to evaluate the potential performance of four of the designs, as presented here. The enzyme-catalyzed reactions were modeled using mixed quantum and molecular mechanics (QM/MM) calculations in the contex...

These projects reflect the core appearances that give rise to the Liar paradox (and its ilk). Semantic paradoxes arise, at least in part, from the appearance that we can ‘exhaustively characterize’ all sentences of our language in terms of ‘semantically significant’ predicates, and truly do as much in our language. Consider the classical picture according to which our semantically significant p...

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We introduce a family of q-analogues of the binomial distribution, which generalises the Stieltjes-Wigert-, Rogers-Szegö-, and Kemp-distribution. Basic properties of this familiy are provided and several convergence results involving the classical binomial, Poisson, discrete normal distribution, and a family of q-analogues of the Poisson distribution are established. These results generalise co...

Otoacoustic emissions (OAEs) are a class of acoustic signals that are generated in the cochlea and transmitted backward to the ear canal through the middle ear. This is attributed to the active nonlinear mechanism in the cochlea [Kemp 1978]. Distortion product otoacoustic emissions (DPOAEs) are a special type of OAEs generated in response to two pure tone acoustic stimuli with sound pressure le...

Heart rate variability (HRV) is a measure of autonomic nervous system activity, which reflects an individual's ability to adapt to physiological and environmental changes. Low resting HRV has been linked to several mental health conditions, including depression, anxiety, and alcohol dependence (Kemp et al. in Biological Psychiatry 67(11):1067-1074, 2010. doi:10.1016/j.biopsych.2009.12.012; Kemp...