نتایج جستجو برای: keratinization
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The hair follicle consists of several distinctive epidermal cell layers. The hair root, which undergoes keratinization, is surrounded by two sheaths: the inner root sheath (IRS) and the outer root sheath (ORS). The ORS is continuous with the basal layer of the epidermis. Its cells do not keratinize in situ, unlike IRS. We have previously demonstrated that keratinization of the ORS was prevented...
Olmsted syndrome (OS) is a rare congenital disorder characterized by palmoplantar and periorificial keratoderma, alopecia in most cases, and severe itching. The genetic basis for OS remained unidentified. Using whole-exome sequencing of case-parents trios, we have identified a de novo missense mutation in TRPV3 that produces p.Gly573Ser in an individual with OS. Nucleotide sequencing of five ad...
Gliicksmann showed that scar tissue in wounds is produced by perivascular fibroblasts and not by the resident fibroblasts in the dermis. The section on keratinization contains an excellent summary of the investigations into hair growth patterns of various species. This work has played an important role in our understanding of the process of keratinization although the reason for the intense int...
Changes in the skin are amongst the earliest signs of a definite vitamin A deficiency which c'an be diagnosed. For many years now, it has been known that one of the most important functions of vitamin A is its influence in maintaining the structural integrity of epithelial cells. Masson (1933) indeed, thought that vitamin A was necessary for some particular metabolic process peculiar to all epi...
Porokeratotic eccrine and hair follicle nevus is a very rare non-hereditary disorder of keratinization with eccrine and hair follicle involvement with only 9 cases described in the literature. In 2009 the term porokeratotic anexial ostial nevus was proposed to comprehend porokeratotic eccrine and hair follicle nevus and a related and more common process without follicular involvement: porokerat...
Erythrosis pigmentosa peribuccalis (Brocq) (or erythrosis pigmentosa mediofacialis) and erythromelanosis follicularis faciei et colli, have been regarded as different disorders, mainly because the first occurs on the mediofacial area and is common in women and the second mostly occurs pre-auricularly in men. Both conditions show histological signs of abnormal follicular keratinization with tele...
Genital porokeratosis is a rare form of porokeratosis which can occur in two ways : in isolated form or as a part of disseminated porokeratosis. The former one is much rarer and less than 50 such cases of isolated involvement of genitalia in porokeratosis has been reported so far. Being a inherited disorder of keratinization, usual mode of heritance is autosomal dominant. The aim of present rep...
Darier disease (DD) is a rare dominantly inherited genodermatosis characterized by loss of intercellular adhesion (acantholysis) and abnormal keratinization. DD is often difficult to manage. Numerous treatments have reportedly been used for the treatment of DD, with limited success. Systemic retinoids are considered the drug of choice for treating DD. However, their use is limited by potential ...
Darier's disease is a rare autosomal dominant genodermatosis. It has an estimated prevalence of 1 in 55,000 to 100,000 individuals, regardless of gender. It is characterized by multiple keratotic papules on the seborrheic areas of the trunk, scalp, forehead and flexures, and the clinical picture is worsened by heat, sun exposure, perspiration and mechanical trauma. Histopathology observed loss ...
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