Pityriasis rubra pilaris is a rare chronic inflammatory papulo-squamous skin disease, the pathogenesis of which still unclear. The pathological essence disease associated with violation keratinization against background hyperactivity keratinocytes subsequent inflammation, as well vitamin A dysmetabolism and weakening protein-binding fiction liver. Unfortunately, treatment complex inconsistent i...

In both the initial biopsy and the complete excision of the lesion, specimens were obtained for hematoxylin-eosin staining. Both specimens showed a well-defined, unencapsulated cystic tumor formed by several different-sized lobules composed of an external layer of basaloid cells and several layers of eosinophilic spindle cells with abrupt keratinization (Fig. 2). No atypia or mitotic figures we...

An alkaline phosphatase that exhibited immunological specificity towards the mouse uterus was liberated in the serum during uterine carcinogenesis induced by dimethylbenzanthracene. A correlation was observed between the presence of neoplastic lesions and the appearance of this alkaline phosphatase in the serum. This specific protein, which was immunohistochemically localized in the endometrial...

Acne is a common disease that in cases of extreme disfiguration can have severe consequences for the personality development of young people and is associated with a relatively high prevalence of depression and suicide. Spontaneous regression is common, but acne can extend into the fourth and fifth decades of life. The pathogenesis is still not fully understood. Factors promoting the developmen...

Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit. Its pathogenesis multifactorial and involves overlap between four main processes: alteration keratinization, increased sebum production, colonization with Cutibacterium acnes, inflammation. The role oxidative stress (OS) has been intensively studied in conditions such as psoriasis, vitiligo, or atopic dermatitis. Ho...

Buschke-Fisher-Brauer keratoderma is a rare hereditary autosomal dominant disease of incomplete penetrance. Important differential diagnoses include other palmoplantar keratinization disorders, acquired or hereditary, which is done based on the histopathological findings. This diagnosis alerts especially about the possibility of associated neoplasms. Treatment involves topical keratolytic agent...

In both the initial biopsy and the complete excision of the lesion, specimens were obtained for hematoxylin-eosin staining. Both specimens showed a well-defined, unencapsulated cystic tumor formed by several different-sized lobules composed of an external layer of basaloid cells and several layers of eosinophilic spindle cells with abrupt keratinization (Fig. 2). No atypia or mitotic figures we...

Keratinization disorders Epidermolytic hyperkeratosis KRT1, KRT10 12 Epidermolytic PPK KRT9 12 Non-epidermolytic PPK KRT16 12 Vohwinkel’s syndrome LOR 31 Ichthyosis bullosa Siemens KRT2e 64 Pachonychia congenita type 1/2 KRT6a, 16, 17 64 X-linked ichthyosis STS 7 Lamellar ichthyosis TGM1 31 Palmoplantar keratoderma GJB2 61 with deafness Erythrokeratodermia variabilis GJB3 60 Darier’s disease AT...

OBJECTIVE To observe the effects of low intensity laser therapy in inflammation, wound healing and epithelialization of island skin grafts. METHODS Twenty rats were subjected to this grafting technique and divided subsequently into two equal groups, one treated with laser and the other control. RESULTS there was less inflammation, faster healing, epithelialization and keratinization in the ...