Tracer methods for VLDL-TG kinetics vary in their ability to account for the effect of tracer recycling, which can influence the calculation of VLDL-TG fractional catabolic rates (FCRs). We evaluated a novel approach, involving stable isotopically labeled glycerol or palmitate tracers in conjunction with compartmental modeling, for measuring VLDL-TG kinetics in normolipidemic human subjects. Wh...

Injectable formulations of L-adrenaline are commonly used in emergency medicine. Despite numerous studies, the comparative contribution and kinetics of the L-adrenaline inactivation pathways during storage have not been conclusively evaluated. We examined the kinetics of L-adrenaline degradation in a prospective study and determined the extent of drug inactivation by different pathways during a...

Various modeling strategies have been developed to convert regional [(18)F]fluorodeoxyglucose ([(18)F]FDG) concentration measured by positron emission tomography (PET) to a measurement of physiological parameters. However, all the proposed models have been developed and tested mostly for brain studies. The purpose of the present study is to select the most accurate model for describing [(18)F]F...

Purpose: We constructed a biomarker-survival modeling framework to explore the relationship between prostate-specific antigen (PSA) kinetics and overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients following oral administration of 1,000 mg/day of abiraterone acetate (AA). Experimental Design: The PSA-survival modeling framework was based on data from two pha...

PURPOSE We constructed a biomarker-survival modeling framework to explore the relationship between prostate-specific antigen (PSA) kinetics and overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients following oral administration of 1,000 mg/day of abiraterone acetate (AA). EXPERIMENTAL DESIGN The PSA-survival modeling framework was based on data from two pha...

New modeling approaches are needed to tackle the complexity of cell signaling systems. An emerging approach is rule-based modeling, in which protein-protein interactions are represented at the level of functional components. By using rules to represent interactions, a modeler can avoid enumerating the reachable chemical species in a system, which is a necessity in traditional modeling approache...

the hcci combustion process is initiated due to auto-ignition of fuel/air mixture which is dominated by chemical kinetics and therefore fuel composition has a significant effect on engine operation and a detailed reaction mechanism is essential to analysis hcci combustion. a single zone-model permits to have a detailed chemical kinetics modeling for practical fuels. in this study a single-zone ...

Polyanhydrides are a class of degradable biomaterials that have shown much promise for applications in drug and vaccine delivery. Their properties can be tailored for controlled drug release, drug/protein stability, and immune regulation (adjuvant effect). Identifying the relationship between the molecular structures of the polymers and the drug release kinetics profiles would help understand t...

Single-channel recording provides high resolution information on gating mechanisms of ion channels that are generally difficult to obtain from macroscopic measurements. Analysis of the data, however, has proven to be challenging. Early approaches rely on half-amplitude threshold detection to idealize the record into dwell-times, followed by fitting duration histograms to resolve kinetics. More ...

This article discusses the possibilities to study relevant quality aspects of food, such as color, nutrient content, and safety, in a quantitative way via mathematical models. These quality parameters are governed by chemical, biochemical, microbial, and physical changes. It is argued that the modeling of such quality aspects is in fact kinetic modeling. Therefore, attention is paid to chemical...