The CCAAT/enhancer binding protein A (C/EBPA) is vital for establishing normal hepatic energy homeostasis and moderating hepatocellular growth. CEBPA loss-of-function mutations identified in acute myeloid leukemia patients support a tumor suppressor role for C/EBPA. Recent work showed reductions of C/EBPA levels in human hepatocellular carcinoma with the reductions correlating to tumor size and...

BACKGROUND Manganese superoxide dismutase (MnSOD) is a mitochondrial antioxidant enzyme that is down-regulated in a majority of cancers. Due to this observation, as well as MnSOD's potent antioxidant enzymatic activity, MnSOD has been suggested as a tumor suppressor for over 30 years. However, testing this postulate has proven difficult due to the early post-natal lethality of the MnSOD constit...

The liver is the major organ responsible for the uptake of modified low-density lipoprotein (LDL) from the blood circulation, with endothelial and Kupffer cells as major cellular uptake sites. Scavenger-receptors, which include various classes, are held responsible for this uptake. Mice deficient in scavenger-receptor class A types I and II were created and the fate of acetylated LDL (Ac-LDL) i...

The resonances of SI engine combustion chambers are slightly excited during normal combustion but strongly excited by knock. In order to avoid knocking combustions extensive knowledge about knock and its effects is necessary. In this paper the combustion chamber of a serial production engine is modeled by finite elements. Modal analyses are performed in order to gain information about the reson...

In this paper we consider a basic problem in the layout of VLSI-circuits, the channel-routing problem in the knock-knee mode. We show that knock-knee channel routing with 3-terminal nets is NP-complete and thereby settling a problem that was open for more than a decade. In 1987, Sarrafzadeh showed that knock-knee channel routing with 5-terminal nets is NP-complete (Sarrafzadeh, 1987). Furthermo...

In order to detect knock in spark ignition engines, usually structure-borne sound signals measured by acceleration sensors mounted on the engine housing are analyzed. Earlier investigations have shown that using linear, time variant filtered structure-borne sound signals as approximated pressure signal instead improves knock detection significantly. But this method is computationally too expens...

We describe a probabilistic method for identifying characters in TV series or movies. We aim at labeling every character appearance, and not only those where a face can be detected. Consequently, our basic unit of appearance is a person track (as opposed to a face track). We model each TV series episode as a Markov Random Field, integrating face recognition, clothing appearance, speaker recogni...

Given the multiple differences between mice and men, it was once thought that mice could not be used to model atherosclerosis, principally a human disease. Apolipoprotein E-deficient (apoEKO) mice have convincingly changed this view, and the ability to model human-like plaques in these mice has provided scientists a platform to study multiple facets of atherogenesis and to explore potential the...