1 Laboratoire de Chimie Bio-Inspirée et D’Innovations Ecologiques, UMR 5021 Centre National de la Recherche Scientifique – Université de Montpellier, Grabels, France, 2 INERIS, Clean and Sustainable Technologies and Processes Unit, DRC/RISK, Parc Technologique Alata, BP2, Verneuil-en-Halatte, France, 3 Institut Jean Lamour, UMR 7198, Université de Lorraine, Centre National de la Recherche Scien...

An efficient and straightforward four-component synthetic protocol has been developed to synthesize imidazo[1,2-a]pyridines and imidazo[1,2,3-ij][1,8]naphthyridine derivatives incorporating medicinally privileged heterosystems from heterocyclic ketene aminals, aldehydes, diketene, and amines via cascade reactions, including diketene ring-opening, Knoevenagel condensation, aza-ene reaction, imin...