Policy Commercial Members: Managed Care (HMO and POS), PPO, and Indemnity Medicare HMO Blue and Medicare PPO Blue Members Genetic tests for the screening, detection, and management of prostate cancer are INVESTIGATIONAL. This includes, but is not limited to the following:  Single-nucleotide polymorphisms (SNPs) for risk assessment, or  PCA3 for disease diagnosis and prognosis, or  TMPRSS fus...

Genetics is an area of biology that focuses on the study of heredity and the investigation of inherited characteristics. In the past twenty years, initiatives such as the Human Genome Project have enabled us to amass great knowledge on the relationships between genes, mutations and the molecular pathways that are involved in disease diagnosis and prognosis. Nevertheless, there are still a numbe...

Oral cancer is mostly preventable. As the mouth is easily accessible for self or clinical examination early diagnosis of the malignancy is possible, and it greatly increases survival rates.3 The prognosis of oral cancer is poor with lowest survival rates of <50%, within a 5-year period. In spite of advances in the diagnosis and treatment of oral cancer, the proportion of oral cancer cases diagn...

Balamuthia amoebic encephalitis is a rare infection but it almost always proves fatal with the mortality rate of more than 95%. Thus it is not surprising that the majority of cases are identified at the post-mortem stage. Early diagnosis followed by aggressive treatment may lead to successful prognosis for the patient. The clinical diagnosis requires a high level of suspicion, awareness of the ...

Neonatal and infantile erythroderma is a diagnostic and therapeutic challenge. Numerous underlying causes have been reported. Etiologic diagnosis of erythroderma is frequently difficult to establish, and is usually delayed, due to the poor specificity of clinical and histopathologic signs. Differential diagnosis of erythroderma is a multi-step procedure that involves clinical assessment, knowle...

This paper presents an approach of model-based diagnosis for the health monitoring of hybrid systems. These systems have both continuous and discrete dynamics. Modified Particle Petri Nets, initially defined in the context of hybrid systems mission monitoring, are extended to estimate the health state of hybrid systems. This formalism takes into account both uncertainties about the system knowl...

Integrated Systems Health Management includes fault detection, fault diagnosis (or fault isolation), and fault prognosis. We define prognosis to be detecting the precursors of a failure, and predicting how much time remains before a likely failure. Algorithms that use the data-driven approach to prognosis learn models directly from the data, rather than using a hand-built model based on human e...

Purpose:Microarray studies indicate medulloblastoma comprises distinct molecular disease subgroups, which offer potential for improved clinical management. Experimental Design: Minimal mRNA expression signatures diagnostic for the Wnt/Wingless (WNT) and Sonic Hedgehog (SHH) subgroups were developed, validated, and used to assign subgroup affiliation in 173 tumors from four independent cohorts, ...

Introduction: Squamous cell carcinoma (SCC) of the breast is a rare tumour. Histology and immunohistochemistry are key to diagnosis. Treatment similar other cancers. Its prognosis poor. We report our first documented case with aim describing diagnostic therapeutic features. Case report: A 33-year-old married woman was presented an ulcerated oozing mass right that had been evolving for one year....