A novel C-homoprotoberberine alkaloid, Hediamine (2), has been isolated from the roots of Berberis actinucantha (Berberidaceae). Conclusive proof for the structure of hediamine was obtained by its comparison with the isomeric lactam (4), by chemical transformation, and by means of spectroscopic techniques (UV, IR, MS, NMR).

 Background: Behçet’s disease (BD) is a multi-system inflammatory vascular disorder with auto immunity background. It is a genetic disease that may be affected by environmental factors. Behçet’s disease may involve different organs like urogenital, skin, eyes and gastrointestinal system. According to geographic area and genetic predisposition, prevalence of the disease is different. The aim of...

the prevalence of vesicoureteral reflux (vur) among siblings of children with vur has been reported to be from 4.7% to 51%. the incidence of vur in the general population is less than 1% but it is high in risk groups. in a prospective study we started identifying the incidence and severity of vur and renal parenchymal lesions in the siblings of patients known to have urinary tract infection (ut...

Every man desires to live long, but no man would be old. Understanding frailty—the concept of vulnerability to adverse health outcomes of people of the same chronological age—continues to motivate research by geriatricians, epidemiologists, sociologists and laboratory-based scientists. While some clinicians have embraced frailty as the Holy Grail of geriatric medicine [1] or advocated it as ano...

AspectJ is a so-called general-purpose aspect-language which tries to solve the problem of crosscutting code. An often uttered criticism of AspectJ is that there is no underlying concept in the implemented language features and that those features are rather arbitrary chosen instead of being based on any theoretical foundations. This paper shows beyond the the context of crosscutting and tangli...