We examined the hypothesis that disturbance of laminar flow promotes the attachment of leukocytes to the vessel wall in regions where the wall shear stress is otherwise too high. Isolated neutrophils, lymphocytes, or monocytes were perfused through chambers with backward-facing steps so that vortices occurred with well-defined reattachment of flow. Wall shear stresses downstream in reestablishe...

The propagation of elastic waves in a box under direct shear, filled with glass beads and being sheared at constant rates, is studied experimentally and theoretically. The respective velocities are shown to be essentially unchanged from that in a static granular system under the same pressure and shear stress but without a shear band. Influence of shear band on sound behaviors are also briefly ...

Numerical results are presented for the shock-boundary layer interactions in a hypersonic flow over a sharp leading edge compression corner. In this study, a second- order Godunov type scheme based on solving a Generalized Riemann Problem (GRP) at each cell interface is used to solve thin shear layer approximation of laminar Navier-Stokes (N-S) equations. The calculated flow-field shows general...

The effect of a temporal gradient in shear and steady shear on the activity of extracellular signal-regulated protein kinases 1 and 2 (ERK1/ERK2), c-fos, and connexin43 (Cx43) in human endothelial cells was investigated. Three laminar flow profiles (16 dyn/cm(2)), including impulse flow (shear stress abruptly applied for 3 s), ramp flow (shear stress smoothly transitioned at flow onset), and st...

One of the most common methods to measure soil mechanical properties (namely cohesion and internal friction angle) is direct shear box test. In this paper the development of a three-dimensional (3D) discrete element soil model for simulation of a cohesive soil’s direct shear test is presented. The aim was to calibrate the properties of the Hertz-Mindlin with bonding contact model available in E...

Laminar shear stress activates c-Jun NH(2)-terminal kinase (JNK) by the mechanisms involving both nitric oxide (NO) and phosphatidylinositide 3-kinase (PI3K). Because protein kinase B (Akt), a downstream effector of PI3K, has been shown to phosphorylate and activate endothelial NO synthase, we hypothesized that Akt regulates shear-dependent activation of JNK by stimulating NO production. Here, ...