Pavlovian to Instrumental Transfer (PIT) refers to the behavioral phenomenon of increased instrumental responding for a reinforcer when in the presence of Pavlovian conditioned stimuli that were separately paired with that reinforcer. PIT effects may play an important role in substance use disorders, but little is known about the brain mechanisms that underlie these effects in alcohol consumers...

Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of intravenously injected antibodies with the acute toxicity induced by photosensitizers after exposure to NIR-light. Herein, we evaluate the efficacy of NIR-PIT in preventing lung metastases in a mouse model. Lung is one of the most common sites for developing metastases, but it also has the deep...

The pit organs of elasmobranchs (sharks, skates and rays) are free neuromasts of the mechanosensory lateral line system. Pit organs, however, appear to have some structural differences from the free neuromasts of bony fishes and amphibians. In this study, the morphology of pit organs was investigated by scanning electron microscopy in six shark and three ray species. In each species, pit organs...

It is widely held that the interaction between instrumental and Pavlovian conditioning induces powerful motivational biases. Pavlovian-Instrumental Transfer (PIT) is one of the key paradigms demonstrating this effect, which can further be decomposed into a general and specific component. Although these two forms of PIT have been studied at the level of amygdalar subregions in rodents, it is sti...

Photodynamic therapy (PDT) is a promising approach for the treatment of superficially localized tumors. A limitation, however, is the lack of selectivity of the photosensitizers, which can result in severe toxicity. In this overview, the possibilities for using monoclonal antibodies (MAbs) for selective delivery of photosensitizers to tumors, are discussed. This approach is called photoimmunoth...

We consider the problem of finding an optimal mining sequence for an open pit during a number of time periods subject to only spatial and temporal precedence constraints. This problem is of interest because such constraints are generic to any open-pit scheduling problem and, in particular, because it arises as a Lagrangean relaxation of an open-pit scheduling problem. We show that this multi-pe...

Content Centric Network (CCN) is an emerging information centric network design. There are a lot of studies focusing on caching, applications and so on to make CCN getting perfect, while the scalability of Pending Interest Table (PIT) is still one of the primary concerns of high-speed forwarding. In this paper, we make an attempt to compress PIT with bloom filter. This paper has two contributio...

Background: The pit of Phoenix dactylifera contains different compounds such as saturated and unsaturated fatty acids, Zinc, Cadmium, Calcium and Potassium which could improve steroidogenesis. In this research, effect of phoenix dactylifera pit powder was evaluated on female rat reproduction. Materials and Methods: In this experimental study, 50 female wistar rats were divided in 5 groups of 10...

BACKGROUND Pit latrines are one of the most common human excreta disposal systems in low-income countries, and their use is on the rise as countries aim to meet the sanitation-related target of the Millennium Development Goals. There is concern, however, that discharges of chemical and microbial contaminants from pit latrines to groundwater may negatively affect human health. OBJECTIVES Our g...