OBJECTIVES/HYPOTHESIS This study was designed to assess the feasibility of the submucosal infusion technique combined with microflap dissection as a radical therapeutic and diagnostic option for precancerous laryngeal leukoplakia. STUDY DESIGN Retrospective study. METHODS Severe dysplasia or carcinoma in situ was diagnosed after phonomicrosurgical dissections in 25 patients with unilateral ...

Descriptions of vocal fold lesions related to autoimmune diseases are rare in the literature, and focus mainly on rheumatoid nodules. This is the first report in which autoimmune diseases were promptly suspected by the observation of a unique white transverse submucosal lesion in the vocal fold during clinical examination. This lesion, reported only in autoimmune disease, has been called the ba...

BACKGROUND Prediction of which laryngeal dysplasia cases will progress to cancer is poorly achieved. The differential expression of biomarkers in dysplastic and cancerous lesions may help to improve this. METHODS We carried out a systematic review of laryngeal dysplasia biomarkers. Risk ratios were calculated for each biomarker. Individual study data were pooled only for the biomarker p53. ...

The Papillomaviruses are DNA viruses which belong to the Papova family, having a great affinity for epithelial tissue. They can produce proliferative lesions either in the skin or mucosa, either in man or other animals. Various kinds of lesions, mainly benign, are caused by numerous types of human papillomavirus (HPV) involving the well-known verruca vulgaris, respiratory laryngeal papillomatos...

UNLABELLED Laryngeal papillomatosis is the most frequent benign neoplasia in children. It is caused by HPV 6 and 11. The lesions are exophytic and highly recurrent, compromising the airway mucosa, mainly the larynx. Study design--clinical prospective. AIMS To show morphologic alterations of the epithelium (light and electron microscopy) in the HPV-6 lesions. METHODS Specimens of laryngeal l...

UNLABELLED Despite the growing experience obtained from the National Pro-Voice Campaigns in screening individuals with laryngeal alterations, we still have not established which would be the best assessment method: speech and hearing screening alone, laryngoscopy alone, or a joint work with physicians and speech therapists doing the screening together. AIM the goal of the present study was to...

BACKGROUND This study aimed at the evaluation of the expression of metallothionein (MT) in laryngeal carcinoma and its correlation with the expression of Ki-67 antigen and p53 protein and selected clinical and pathological variables in view of their potential prognostic significance. MATERIALS AND METHODS Sixty-five laryngeal cancer patients were retrospectively analysed. Expression of MT, Ki...

Ewing sarcomas (EWS) are highly malignant neoplasms of mesenchymal origin that rare in the head and neck. Only a few laryngeal EWS have been reported literature. We report 47 years-old man who visited our hospital for medical help after 5 months hoarseness sore throat. Computed tomography (CT) showed uneven thickening epiglottis fold, right vocal cord, anterior union. In addition, fluoro-18-flu...

Endoscopy is essential for the diagnosis and treatment of cancers derived from the larynx. However, a laryngoscope with conventional white light (CWL) has technical limitations in detecting small or superficial lesions on the mucosa. Narrow band imaging especially combined with magnifying endoscopy (ME) is useful for the detection of superficial squamous cell carcinoma (SCC) within the orophary...

A 62-year-old woman smoker presented with 1 week of common cold and worsening hoarseness. She presented with dyspnea, which had been worsening over the past few days. On the initial examination in theemergency room, she couldnot liedown, stridor was evident and fiberoptic laryngoscopy revealed large laryngeal mass causing airway obstruction. Large laryngeal mass disappeared in subglottis with i...