Background & Aims: Many studies have demonstrated that Vitamin D has an important role in cell growth and proliferation and vitamin D receptor polymorphism has significant relationship with colorectal cancer (CRC). The aim of this study was to assess the incidence of VDR rs 2238136 polymorphism in Iranian population and to investigate the relationship between this single nucleotide polymorphism...

Objective(s):Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. Materials and Methods:We utilized a polymerase chain reaction (PCR) restriction fragment length polymorphi...

the aim of the study was to explore the mechanisms underlying the association of birth weight with later body mass index (bmi) from the biochemical markers related to metabolism and the apa i polymorphism in igf-ii gene.a total of 300 children were selected randomly from the macrosomia birth cohort in wuxi, china. the height and weight were measured and blood samples were collected. plasma conc...

aim : the present study evaluated the association between g241r and k469e polymorphisms of intercellular adhesion molecule 1 gene and inflammatory bowel disease in iranian population.   background : inflammatory bowel disease including ulcerative colitis and crohn’s disease, is a chronic idiopathic inflammatory disease of the gastrointestinal tract. there are two single base polymorphisms of in...

A highly efficient, rapid, and reliable PCR-based method for distinguishing Lactococcus lactis subspecies (L. lactis subsp. lactis and L. lactis subsp. cremoris) is described. Primers complementary to positions in the glutamate decarboxylase gene have been constructed. PCR analysis with extracted DNA or with cells of different L. lactis strains resulted in specific fragments. The length polymor...

background: aspergillus species are associated with allergic bronchopulmonary disease, mycotic keratitis, otomycosis, na­sal sinusitis and invasive infection. in this study, we developed a pcr-single strand confomational polymorphism method to identify the most common aspergillus species and we showed some advantages of this method comparing a pcr-restric­tion fragment length polymorphism with ...

objective(s):cytochrome p-450 1a1 is an important enzyme in the first phase of the metabolism of some carcinogens such as polycyclic aromatic hydrocarbons (pahs), as well as estrogen. the present study evaluates the existence of cyp1a1 polymorphism in a number of breast cancer samples. materials and methods: one hundred breast cancer patients and the same number of healthy controls were analyze...

the e-selectin mediates the interaction of activated endothelial cells with leukocytes and plays a fundamental role in the pathogenesis of asthma. it has been suggested that an s/r (serine128arginine) polymorphism of e-selectin alters ligand binding function. our purpose in this study was to determine whether this serine128arginine polymorphism influences the risk of asthma and also to analyze ...

PURPOSE To investigate the degree of heteroplasmy of the 11778 mtDNA mutation in Chinese patients with Leber's hereditary optic neuropathy (LHON). METHODS Seventeen Chinese Leber's pedigrees, including 24 patients, 17 unaffected maternal lineages, 4 internal controls, and 6 unrelated controls, were screened for the 11778 mtDNA mutation. This was carried out by analysis of the restriction frag...

Amplified fragment length polymorphisms are a PCR-based genetic tool used to mark the presence or absence of alleles in a DNA sample. This tool has typically been used for genetic analysis in plants, but research is now being done to see if it is a reliable source for paternity analysis in animals. Samples of Orconectes limosus were collected from Quinebaug River during a previous study and mat...