نتایج جستجو برای: lentiviral vectors

تعداد نتایج: 71689  

Journal: :Proceedings of the National Academy of Sciences 2006

Journal: :Molecular therapy : the journal of the American Society of Gene Therapy 2008
Gerhard Bauer Mo A Dao Scott S Case Todd Meyerrose Louisa Wirthlin Ping Zhou Xiuli Wang Phillip Herrbrich Jesusa Arevalo Susie Csik Dianne C Skelton Jon Walker Karen Pepper Donald B Kohn Jan A Nolta

Serious adverse events in some human gene therapy clinical trials have raised safety concerns when retroviral or lentiviral vectors are used for gene transfer. We evaluated the potential for generating replication-competent retrovirus (RCR) and assessed the risk of occurrence of adverse events in an in vivo system. Human hematopoietic stem and progenitor cells (HSCs) and mesenchymal stem cells ...

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