ObjectiveTo describe the features related to patients with Covid-19 admitted Unimed Recife hospitals, Recife, Brazil, evaluating demographic data, lethality, use of a mechanical ventilator, presence associated diseases, need ICU, among other aspects prognosis these patients.MethodData were collected from DRG Brazil health management platform, including period March 16, 2020, when first patient ...

Cinnamomum species have long been used as spices. The preliminary bioactive constituent’s identification and brine shrimp lethality activities of ethanolic extracts of seven Cinnamomum species viz., C. travancoricum, C. walaiwarense, C. wightii, C. verum, C. sulphuratum, C. riparium, and C. perrottetii were evaluated in this study. The results of cytotoxic activity of the bark extracts of seven...

To clarify the possible role of TNF and IL-1 in endotoxic shock, the lethality of rTNF (human and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has long been known to increase the susceptibility to endotoxin, rendered mice susceptible to TNF and IL-1 in terms of mortality. The lethality of endotoxin, TNF, or IL-1 was totally prevented by pretreatment with dexametha...

Background and Aim Acanthamoeba is one of free-living amoebas, which are very abundant in nature. As a amoeba, this parasite has high lethality, especially people with underlying diseases, so researchers always looking for way to combat it. Drug plants good fight species. In study, we aimed investigate the lethal effect extract Oliveria decumbens vent Peganum harmala alcoholic on Acanthamoeba. ...

The human telomeric DNA binding factor TRF1 (hTRF1) and its interacting proteins TIN2, tankyrase 1 and 2, and PINX1 have been implicated in the regulation of telomerase-dependent telomere length maintenance. Here we show that targeted deletion of exon 1 of the mouse gene encoding Trf1 causes early (day 5 to 6 postcoitus) embryonic lethality. The absence of telomerase did not alter the Terf1(ex1...

In mice, running, clonic and tonic convulsions and lethality were assessed following transcorneal (electroshock) current or convulsant drugs, each administered alone and after cannabidiol (CBD) pretreatment. CBD prevented tonic convulsions caused by a convulsant current (CC) 99.99, and by the convulsant dose (CD) 99.99 values of gamma-aminobutyric acid (GABA) inhibitors, 3-mercaptoproprionic ac...

Intracellular pH (pHi) dynamics is increasingly recognized as an important regulator of a range of normal and pathological cell behaviors. Notably, increased pHi is now acknowledged as a conserved characteristic of cancers and in cell models is confirmed to increase proliferation and migration as well as limit apoptosis. However, the significance of increased pHi for cancer in vivo remains unre...