نتایج جستجو برای: leukocyte mycobacterium defect

تعداد نتایج: 173782  

Journal: :Annual review of medicine 1987
D C Anderson T A Springer

Leukocyte adhesion deficiency (LAD) is a recently recognized autosomal-recessive trait characterized by recurrent bacterial infections, impaired pus formation and wound healing, and abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells. Features of this disease are attributable to deficiency (or absence) of cell surface expression of a ...

Journal: :Infection and immunity 1997
D D Riedel S H Kaufmann

Macrophages (MAC) and polymorphonuclear granulocytes (PNG) are professional phagocytes which perform essential functions in antibacterial defense. The intracellular bacterium Mycobacterium tuberculosis persists and replicates in resting macrophages. Although it is generally assumed that activated MAC are central to protection against M. tuberculosis, PNG may also contribute to defense. We wonde...

2016
J. Frau D. Cossu C. Sardu G. Mameli G. Coghe L. Lorefice G. Fenu S. Tranquilli L. A. Sechi M. G. Marrosu E. Cocco

BACKGROUND Amongst Sardinians the human leukocyte antigen (HLA) DRB1-DQB1 haplotypes *15:02-*06:01, *16:01-*05:02, *14:01-4-*05:03 are protective for multiple sclerosis (MS), while *13:03-*03:01, *04:05-*03:01, *03:01-*02:01, *15:01-*06:02 and Mycobacterium avium subspecies paratubercolosis (MAP) are predisposing factors. We studied the correlation between MAP and HLA. METHODS Five hundred th...

2015
Dan Wamala Helen Koyokoyo Buteme Samuel Kirimunda Gunilla Kallenius Moses Joloba

BACKGROUND Mycobacterium tuberculosis (Mtb) is reported to infect about a third of the world's population but only 10% are thought to develop active tuberculosis (TB) disease. Host immunity regulated by human leukocyte antigens (HLA) is an important determinant of the outcome of the disease. Here we investigate HLA class II gene polymorphisms in susceptibility to TB, and whether particular HLA ...

Journal: :Blood 2006
Yvonne Helmus Jonas Denecke Sviatlana Yakubenia Peter Robinson Kerstin Lühn Diana L Watson Paraic J McGrogan Dietmar Vestweber Thorsten Marquardt Martin K Wild

Leukocyte adhesion deficiency II (LAD II) is a rare congenital disease caused by defective fucosylation leading to immuno-deficiency and psychomotor retardation. We have previously identified the genetic defect of LAD II in a patient whose Golgi GDP-fucose transporter (GFTP) bears a single amino acid exchange that renders this protein nonfunctional but correctly localized to the Golgi. We now r...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1992
D E Shuster M E Kehrli M R Ackermann R O Gilbert

Two point mutations were identified within the gene encoding bovine CD18 in a Holstein calf afflicted with leukocyte adhesion deficiency (LAD). One mutation causes an aspartic acid to glycine substitution at amino acid 128 (D128G) in the highly conserved extracellular region of this adhesion glycoprotein, a region where several mutations have been found to cause human LAD. The other mutation is...

Journal: :iranian journal of microbiology 0
m shamaei masih daneshvari hospital, darabad, niavaran sq, tehran, iran. m marjani masih daneshvari hospital, darabad, niavaran sq, tehran, iran. p farnia mycobacteriology research center,nritld, masih daneshvari hospital, shahid beheshti university of medical.sciences, tehran, iran. p tabarsi mycobacteriology research center,nritld, masih daneshvari hospital, shahid beheshti university of medical.sciences, tehran, iran. d mansouri masih daneshvari hospital, darabad, niavaran sq, tehran, iran and chronic respiratory disease research center, nritld, masih daneshvari hospital, shahid beheshti university of edical.sciences,tehran, iran.

non-tuberculosis mycobacteria (ntm), as certain species of mycobacteria, can affect human in several ways. in the preceding years, the rate of ntm detection has risen in both immunocompromised and immunocompetent patients. on the other hand, several reports have debated the possibility of co-infection of both mycobcateriu tuberculosis (mtb) and ntm in individuals that puts the role of ntm in di...

Journal: :The Journal of clinical investigation 1968
D B Windhorst A R Page B Holmes P G Quie R A Good

The leukocyte-phagocytic function test which was found to be abnormal in boys with fatal granulomatous disease of childhood has been found to be abnormal to an intermediate extent in their mothers. Nine of nine mothers were shown to be abnormal, whereas none of eight fathers and none of five healthy brothers exhibited a defect. 10 of 16 female siblings were abnormal to the same degree as their ...

2017
Vincenzo Torraca Claudia Tulotta B. Ewa Snaar-Jagalska Annemarie H. Meijer

CXC chemokine receptor 4 plays a critical role in chemotaxis and leukocyte differentiation. Furthermore, there is increasing evidence that links this receptor to angiogenesis. Using the well-established zebrafish-Mycobacterium marinum model for tuberculosis, angiogenesis was recently found to be important for the development of cellular aggregates called granulomas that contain the mycobacteria...

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