نتایج جستجو برای: lidocaine

تعداد نتایج: 7299  

2016
David Daewhan Kim Nabil Sibai

INTRODUCTION Greater occipital nerve blocks (GONB) have been used for headache but their benefit may be short. Ready et al performed intrathecal injections on rabbits and reported neurologic/histologic changes that required concentrations of at least 8%. Our study tests the hypothesis that the neurolytic effects of GONB with 10% lidocaine can prolong relief. METHODS After an approval from Hen...

Journal: :Archives of pediatrics & adolescent medicine 2008
Jay Pershad Stephanie C Steinberg Teresa M Waters

OBJECTIVE To conduct a cost-effectiveness analysis of anesthetic agents to reduce the pain of peripheral intravenous cannulation in an emergency department (ED) setting. DESIGN Cost-effectiveness analysis in which costs were measured as the cost of the agent plus costs associated with time in the ED using data from our hospital cost accounting system. Outcomes were measured as improvements in...

Journal: :Anesthesiology 2011
Igor Putrenko Stephan K W Schwarz

BACKGROUND The mechanisms that underlie the supraspinal central nervous system effects of systemic lidocaine are poorly understood and not solely explained by Na(+) channel blockade. Among other potential targets is the hyperpolarization-activated cation current, I(h), which is blocked by lidocaine in peripheral neurons. I(h) is highly expressed in the thalamus, a brain area previously implicat...

Journal: :Reactions Weekly 2021

2011
Péter Lukács René Cervenka Xaver Koenig Ágnes Mike Michael Kovar Karlheinz Hilber Hannes Todt

Background The local anesthetic lidocaine is generally believed to reach its binding site in the intracellular vestibule of the voltage-gated sodium channel via the cell membrane. QX222 is a permanently charged, quaternary amine analogue of lidocaine, which can access this binding site via a hydrophilic route across the channel protein. The mutation I1575E of the adult rat muscle-type sodium ch...

2012
Afshin Mansourian Mohammad Askarzadeh Mohammad Shabani Kouros Divsalar

BACKGROUND Duration of spinal anesthesia depends on the type of anesthetic agent, dosage and additive materials such as epinephrine, ephedrine and opioid. We compared the duration of spinal anesthesia with lidocaine 5% with or without epinephrine in addict and non-addict patients undergoing inferior limb fracture surgery. METHODS This single blinded randomized clinical trial was performed on ...

Journal: :Journal of the South African Veterinary Association 2005
R DeRossi A L Junqueira M P Beretta

The objective of the study was to determine the analgesic and systemic effects of subarachnoid administration of xylazine hydrochloride (XY), lidocaine hydrochloride (LI) and their combination (XYLI) in goats. Six healthy goats were used in a prospective randomised study. Three treatments were administered to each goat, with 1-week intervals between each treatment. Treatments consisted of 0.1 m...

2012
Chan Hong Park Sug Hyun Jung Chang Gyu Han

BACKGROUND An intravenous infusion of lidocaine has been used on numerous occasions to produce analgesia in neuropathic pain. In the cases of failed back surgery syndrom, the pain generated as result of abnormal impulse from the dorsal root ganglion and spinal cord, for instance as a result of nerve injury may be particularly sensitive to lidocaine. The aim of the present study was to identify ...

Journal: :Drug delivery 2016
Atul Nayak Hiten Babla Tao Han Diganta Bhusan Das

A study that combines microneedles (MNs) and sonophoresis pre-treatment was explored to determine their combined effects on percutaneous delivery of lidocaine from a polymeric hydrogel formulation. Varying ratios of carboxymethylcellulose and gelatine (NaCMC/gel ranges 1:1.60-1:2.66) loaded with lidocaine were prepared and characterized for zeta potential and particle size. Additionally, variat...

2012
Gamze TAN Gülçin BOLAT Mehmet Ali ONUR Serdar ABACI

The potential application of biochemically modified electrodes was investigated for construction of a drug biosensor. The electrocatalytic response of lidocaine was examined through modified electrodes using the electron transfer ability of hemoglobin (Hb) immobilized on gold film modified with a self-assembled monolayer (SAM) of 3-mercaptopropionic acid (MPA). According to the results of volta...

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