SUMMARY The effect of lidocaine on the ventricular fibrillation threshold was investigated in the anesthetized open-chest dog during paced supraventricular rhythm, during acute ligation of the anterior descending coronary artery, and during premature ventricular contractions. The minimum current (in milliamperes) required to induce ventricular fibrillation was determined by passing a train (100...

BACKGROUND Postoperative sore throat (POST) following general anesthesia with endotracheal intubation is a common complication. We hypothesized that lidocaine jelly applied to the tapered cuff of the endotracheal tube (ETT) might decrease the incidence of POST most commonly arising from endotracheal intubation. METHODS A total of 208 patients under general anesthesia were randomly assigned in...

Bupivacaine is a widely used long-acting local anaesthetic. In clinical practice, a mixture of bupivacaine and lidocaine is often used in order to combine the faster onset of sensory blockade of lidocaine with more profound and longer duration of blockade by bupivacaine. The aim of this study was to compare the cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocai...

We studied the effects of lidocaine (1-5 mg/liter) on the diastolic currents of sheep Purkinje fibers by the two-microelectrode voltage clamp technique to obtain additional information on how lidocaine decreases the slope of spontaneous diastolic depolarization of mammalian Purkinje fibers. During voltage clamps we measured both the magnitude and time course of activation and deactivation of th...

BACKGROUND Pre-emptive intravenous lidocaine infusion is known to improve postoperative pain in abdominal surgery. We assessed the effect of intravenous lidocaine infusion in patients who underwent subtotal gastrectomy. METHODS We conducted a double-blind, placebo-controlled study with patients undergoing subtotal gastrectomy for early gastric cancer divided into 2 groups: 1 group received in...

Lidocaine HCl injection is a sterile product that easily contaminated when opened. The temperature and humidity in the storage conditions also affect quality of drug viewed from UV-Vis spectrophotometric absorption value. aimed this study to find out how effect on profile 2% lydocaine by spectrophotometry. used 27 ampoules lidocaine was qualitatively analyzed using lasted for 14 days first stor...

BACKGROUND Perioperative systemic lidocaine has been shown to have beneficial postoperative analgesic effects. The only previous study examining the use of lidocaine in the outpatient setting did not detect an opioid-sparing effect after hospital discharge. More importantly, it is unknown whether systemic lidocaine provides a better postoperative quality of recovery to patients undergoing ambul...

OBJECTIVE Aim was to assess the efficacy and safety of incisional infiltration of lidocaine and epinephrine vs. lidocaine only to reduce postcesarean section (C/S) pain. MATERIAL AND METHODS It was a prospective, randomized, controlled, double-blinded clinical trial that was conducted in two tertiary hospitals in Egypt and included 153 women undergoing C/S under general anesthesia. They were ...