In a fascinating exposition, Dazeley and Gombocz (1979) study the logical analysis of the verb facere given by St. Anselm of Canterbury in Lambeth Manuscript 59.1 According to St. Anselm, someone slaying a man with a sword is said to facere that the man is dead. Other cases elaborated by St. Anselm include facere non esse, non facere esse, and non facere non esse. From these cases, St. Anselm s...

The cardiovascular actions of suxamethonium were studied in spinal cat preparations, and in cats with intact central nervous systems anaesthetized with a thiopentone, nitrous-oxide and oxygen sequence. Mechanical artificial ventilation of the lungs was maintained throughout. Intra-arterial pressure, standard limb lead electrocardiograms and respiratory movements were recorded. Under these condi...

Due to proven similarities in biotransformation between man and minipig, minipig seems to be the experimental animal of choice for preclinical pharmacokinetic studies when an experiment with a drug exhibiting a great first pass bioelimination (like 5-aminosalicylic acid) is to be realised. On the other hand, both minipig and dog may be suitable species for a pharmacokinetic study with a drug ch...

a 33 yr old man, previously diagnosed with hypothyroidism, presented with decreased level of consciousness and generalized tonic-clonic (gtc) seizure to namazi hospital, shiraz, iran, during april 2015. the patient later referred with another episode of seizure like attack for which he received phenytoin, carbamazepine and levothyroxine and was discharged. during his last admission, the patient...