the antioxidant activity of the melia azedarach was investigated in rats with ethanol-induced erythrocyte damage. chronic administration of ethanol (20% w/v, 2 g/kg.p.o.,daily for four weeks) increased the level of lipid peroxidation (lpo), decreased the activity of superoxide dismutase (sod) and catalase and reduced the content of glutathione (gsh). the concurrent treatment of ethanol-administ...

The present study was designed to investigate the in vivo effects of oral administration of arsenic trioxide (As2O3; 0.5 and 1 mg/kg body weight/day for 45 days) on cerebral hemispheres and cerebellum in male mice, Mus musculus. Arsenic reduced the concentration of glutathione (GSH) in cerebral hemisphere and cerebellum at both the dose levels; while increased lipid peroxidation (LPO) in cerebr...

The ethanolic extract of Pleurotus florida was studied for its free radical scavenging property on different in vitro models like 1,1 -diphenyl-picryl hydrazyl (DPPH)Assay, Ferric Reducing Antioxidant Power (FRAP) assay and in vitro antilipidperoxidative assay using goat liver homogenate and RBC Ghost model. The in vitro Lipid peroxidation (LPO) was inhibited to a good extent by the Pleurotus f...

To assess the neurotoxic effects and redox responses of Aroclor 1254 (A1254) on perinatally exposed rat offspring, A1254 was administered by gavage from gestational day (GD) 6 to postnatal day (PND) 21. Neurobehavioral development, antioxidant enzyme activities, lipid peroxidation (LPO), nitric oxide (NO), and NO synthase (NOS) levels were analyzed in the offspring. Neurobehavioral development ...

Chemopreventive action of wheat grass (Triticum astivum) leaf extract in Swiss albino mice was evaluated. Oral administration of wheat grass leaf extract at a dose level of 20 ml/kg body weight per day at pre, peri, and post-initional phases and in combination group, caused significant variation in tumour incidence and tumour yield as compared to the control group. Moreover, the average latent ...

Many factors are involved in Alzheimer's disease (AD) pathology including tau phosphorylation, amyloid β protein (Aβ) accumulation, lipid dysregulation, oxidative stress, and inflammation. The markers of these pathological processes in cerebral spinal fluid are used currently for AD diagnosis. However, peripheral biomarkers are the need of the hour for large population screening for AD. The mai...

ObjectiveThis study examined the impact of submaximal walking training (WT) on local and systemic nitric oxide (NO) bioavailability, inflammation, oxidative stress in patients with intermittent claudication (IC).MethodsThe employed a randomised, controlled, parallel group design was performed single centre. Thirty-two men IC were randomly allocated to two groups: WT (n = 16, sessions/week, 15 c...

Introduction Oxidative stress has been implicated in the normal ageing process and the pathogenesis of several diseases, including goitre. The aim of the study was to evaluate the relationship between urine lipid peroxidation (LPO) and anthropometric parameters as well as the parameters associated with goitre formation in children. Material and methods The subjects included 172 healthy childr...

AIM After acute spinal cord injury (SCI), a large number of axons are lost by a cascade of pathophysiological events known as a secondary injury. The main aim of the current study was to investigate the potential neuroprotective effects of curcumin on lipid peroxidation (LPO), neurological function, and ultrastructural findings after SCI. MATERIAL AND METHODS Forty adult Wistar albino rats we...

Fipronil is a current use pesticide, widely used in many crops, commonly adsorbed to sediments of aquatic environments. The purpose this study was evaluate the biomarker responses and fipronil distribution pattern different matrixes (fish, sediment water) after juveniles P. lineatus exposure at two environmental concentrations (5.5 82 ?g kg ? ?1 ) fipronil-spiked sediments. levels oxidized prot...