Objective(s): The aim of current study was to evaluate improving effects of pioglitazone as an agonist of peroxisome proliferator-activated receptor gamma (PPARγ), on brain-derived neurotrophic factor (BDNF) and cytokines as well as tissue oxidative damage criteria in the hippocampus in a rat model of lipopolysaccharide (LPS) induced memory impairment.<strong...

Objective(s): Acute lung injury (ALI) has a high mortality rate and is characterized by damage to pulmonary system giving rise to symptoms such as histological alteration, lung tissue edema and production of proinflammatory cytokine. p-Coumaric acid (p-CA), as a phenolic compound, that is found in many types of fruits and vegetables has been reported to exhibit a thera...

Abstract The economic losses caused by uterine infections in ruminants have received increasing attention. Autophagy-related 7 ( ATG7 ) has been demonstrated to be capable of regulating apoptosis, but surprisingly, can both promote and inhibit apoptosis different cellular contexts. However, the role endometrial cell during postpartum period remains unclear. Herein, location expression was deter...

Pasteurella multocida is a Gram-negative multispecies pathogen and the causative agent of fowl cholera, a serious disease of poultry which can present in both acute and chronic forms. The major outer membrane component lipopolysaccharide (LPS) is both an important virulence factor and a major immunogen. Our previous studies determined the LPS structures expressed by different P. multocida strai...

periodontitis (pd) is known to be one of most prevalent worldwide chronic inflammatory diseases. there are several treatments including antibiotics for pd; however, since drug resistance is an increasing problem, new drugs particularly derived from plants with fewer side effects are required. the effects of trans-anethole on il-1 β and tnf-α level in a rat model of pd were investigated and comp...

objective(s): occludin is essential for proper assembly of tight junctions (tjs) which regulate paracellular endothelial permeability. omega-3 polyunsaturated fatty acids (ω-3 pufa) protect endothelial barrier function against injury. materials and methods: we examined anti-inflammatory effect of ω-3 pufa intake (30 mg/kg/day for 10 days) on expression and location of occludin in the aorta of a...

Sepsis is a life-threatening condition often leading to multiple organ failure for which currently no pharmacological treatment available. Endothelial cells (EC) are among the first respond pathogens and inflammatory mediators in sepsis might be sentinel target prevent occurrence of failure. Lipopolysaccharide (LPS) Gram-negative bacterial component that induces endothelial expression adhesion ...

Background: Macrophages activation is the important anti-leishmania immune response. Different signals could affect macrophages development and functional activation. Objectives: In the present study, we compared the effect of Leishmania Soluble Antigen (LSA)and Lipopolysaccharide (LPS) on peritoneal macrophage responses. Appropriate activation of macrophages depends on thesignals they receive ...

Purpose: To investigate the role of nicotinamide phosphoribosyltransferase (NAMPT) in lipopolysaccharide (LPS)-induced damage trophoblastic HTR-8/SVneo cells (HTR8 cells), with aim ultimately providing new therapeutic targets preeclampsia (PE).Methods: Trophoblastic was cultured and treated LPS to mimic PE vitro, while FK866, an antagonist NAMPT, used establish inflammatory model HTR8 cells. We...

Inflammation is the cause and/or result of many diseases in peripheral tissues and central nervous system. Recent findings suggested that inflammation tissue induces an inflammatory response brain activates glial cells, which, turn, induce neuronal cell dysfunction. Therefore, anti-inflammatory compounds are important for suppression chronic prevention disease. The present study revealed microg...