the present study was aimed to evaluate the therapeutic potential of pimpinella tirupatiensis (pt) by assaying the activities of selective mitochondrial enzymes in streptozotocin induced diabetic rats. diabetic rats showed a significant (p < 0.01) reduction in the activities of oxidative enzymes succinate dehydrogenase (sdh), malate dehydrogenase (mdh), glutamate dehydrogenase (gdh) and isocitr...

anti-oxidant effects of propofol (2, 6-diisopropylphenol) were evaluated agains carbon tetrachloridet ccl4 -induced oxidative stress in rat liver. 30 male rats were equally divided in to 6 groups (5 rats each). group i (control), while group ii was given ccl4 (3 ml /kg/day, ip). animals of groups iii received only propofol (10 mg/kg/day, ip). group iv was given propofol+ ccl4. group v was admin...

This study aims to investigate the effects of Dexpanthenol (Dex), a stable alcoholic analogue D-pantothenic acid which has anti-oxidant, antiapoptotic, and antiinflammatory properties, on lipopolysaccharide (LPS)-induced lung damage via caspase-3 (cas-3) vascular cell adhesion molecule-1 (VCAM-1) levels. According experimental plan study, thirty-two Wistar Albino species rats were distributed r...

The present study investigated the effects of E. coli lipopolysaccharide (LPS) induced mastitis model in rat on the activity of antioxidant enzyme systems. To achieve this purpose, E. coli LPS were infused into the mammary gland of 12 rats 72 hr postpartum and compared with 12 rats in control group infused intramammary placebo sterile pyrogene – free, physiological saline. The...

objective: oxidative stress that damages proteins result in aging and age related diseases. the aim of this study is to determine the effect of tocotrienol rich fraction (trf) on the expression of proteins in oxidative stress-induced caenohabditis elegans (c.elegans) which has homologous genes to humans. methods: the worms were treated with trf prior to, after and continuously in separate group...

background: it has been reported that ischemia-reperfusion is associated with augmentation of oxidative stress and its specific and sensitive markers. oxidative stress may cause atrial fibrillation (af) which is a common consequence after cardiac surgery. dietary supplementation with antioxidants might lower the incidence of af following coronary artery bypass graft (cabg) surgery. materials an...

endothelial cell (HUVEC) and bovine aertic endothelial cell surface proteoglycans was significantly decreased by the incubation with SNAP andNOR4, poterrt nitric oxide (NO) donors. NO derived from lipopolysaccharide-stiinulated J774 A-1 cells also decreased the binding of EC-SOD to HUVEC, and this decrease was blocked by NG-nitro-L-arginine, a itric oxide synthase inhibiter. Furthermore. the de...

background: glucocorticoids have several benefits in large animal medicine but apart from their benefits, there are several disadvantages attributed to the use of these drugs. among the disadvantages, disturbance in protein metabolism is one of the side effects of glucocorticoids which has been investigated in human and laboratory animals. objectives: there are no information regarding the effe...

toxic effects of monensin, a polyether antibiotic mainly used as a coccidiostat, have been described in a wide range of animals. the present study was performed to investigate the toxic effects of monensin in goats. seven adult goats were administered sodium monensin, 13.5 mg kg-1, daily for five consecutive days via gastric gavage. monensin toxicity was evaluated by clinical signs, serum bioch...