Persistent lithium-induced neurotoxicity: direct effect of lithium and/or hypernatremia? 7.3.2008 Case report A 54-year-old African-American woman was brought to the emergency department of a university medical center with increased confusion. Over several days prior to presentation, she had become drowsy and disoriented. On the day of her admission she had her clothes on inside out. She did no...

Lithium is one of the most frequently used drugs for treating mood disorders. It is used for both prophylaxis and treatment of bipolar affective disorder. It should be cautiously prescribed and used only when clinically indicated because of narrow therapeutic index and significant toxicity. One of the most alarming and potentially serious complications of lithium carbonate therapy is central ne...

OBJECTIVE To describe a patient with lithium intoxication presenting as acute parkinsonism, adverse metabolic effects and nephrogenic diabetes insipidus (DI). CASE REPORT We report a case of a 67-year-old woman with a bipolar affective disorder who was treated with lithium for 10 years. Under concomitant renal insufficiency and urinary tract infarction, she experienced progressive hand tremor...

From many decades efficacy of lithium salts, as mood stabilizers, has been largely recognized, but their tolerability, in particular during intermediate or long-term treatments is still discussed. The most frequently described side effects can affect several organs. Aim of the study was to evaluate lithium carbonate tolerability after a "brief" (1 month-4 years), "intermediate" (5-9 years) and ...

Lithium not only has a mood-stabilizing effect but also the augmentation effect of an antidepressant, the mechanism of which remains unclear. Although lithium may augment the effect of mirtazapine, this augmentation has not been confirmed. Using a contextual fear conditioning test in rats, an animal model of anxiety or fear, we examined the effect of subchronic lithium carbonate (in diet) in co...

Liquid carbonate-based electrolytes are widely used in lithium ion batteries today. Dry polymer electrolytes are potential candidates for use in secondary lithium batteries because of ease of fabrication, good electrochemical stability, low flammability and toxicity with the ability to form good interfacial contact with electrodes. Conductivity and mechanical properties of dry electrolytes, how...

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Patients who seek dental treatment may have bipolar disorder, and lithium carbonate (LC) is the drug of choice used in the treatment of this disorder. Taking into consideration the controversial results found in the literature, and the possible influence of LC on induced tooth movement, the objective was to evaluate tooth movement induced in rats after administration of lithium carbonate. One h...