UNLABELLED A sequence polymorphism (rs738409, I148M) in patatin-like phospholipid domain containing protein 3 (PNPLA3) is strongly associated with nonalcoholic fatty liver disease (NAFLD), but the mechanistic basis for this association remains enigmatic. Neither ablation nor overexpression of wild-type PNPLA3 affects liver fat content in mice, whereas hepatic overexpression of the human 148M tr...

α-Linolenic (ALA) and linoleic (LA) acids are precursors of long chain polyunsaturated fatty acids (LCPUFAs), FAs with important biochemical and physiological functions. In this process, desaturation reactions catalyzed by Δ5- and Δ6-desaturase play a major role, enzymes that are subjected to hormonal and dietary regulation. The aim of this study was to assess the influence of a high fat diet (...

Our aim in this study was to create a noninvasive and practical method for evaluating metabolic information on the liver (iron content and lipid infiltration) and spine (bone mineral density and marrow fat degeneration) using double gradient-echo with and without the spectral fat suppression technique (double-GRE-FS). We arranged phantoms made of various concentrations of superparamagnetic iron...

context the pnpla3 i148m variant has been recognized as a genetic determinant of liver fat content and a genetic risk factor of liver damage progression associated with steatohepatitis. the i148m variant is associated with many chronic liver diseases. however, its potential association with inflammatory and autoimmune liver diseases has not been established. evidence acquisition we systemically...

Introduction In the past decade, the incidence increase of obesity, diabetes and lipid metabolism disorders involved an epidemic increase of Non-Alcoholic Fatty Liver Diseases (NAFLD) which may affect from 10 to 30% of adults and 13% of children in the occidental population. NAFLD can evolve to Non-Alcoholic Steato-Hepatitis (NASH) and may lead to liver fibrosis up to cirrhosis from which compl...

Three amino acids have been shown to accelerate phospholipid turnover in the liver: methionine, cystine, and cysteine (1). In short intervals after the administration of radioactive phosphorus, greater amounts of labeled phospholipid are deposited in the livers of rats fed these three amino acids than in the livers of control animals. In the case of methionine, this finding lends support to the...

A low carbohydrate diet (LCHD) as well as sodium glucose cotransporter 2 inhibitors (SGLT2i) may reduce glucose utilization and improve metabolic disorders. However, it is not clear how different or similar the effects of LCHD and SGLT2i are on metabolic parameters such as insulin sensitivity, fat accumulation, and especially gluconeogenesis in the kidney and the liver. We conducted an 8-week s...

Heterozygous peroxisome proliferator–activated receptor(PPAR)-deficient (PPAR / ) mice were protected from high-fat diet–induced insulin resistance. To determine the impact of systemic reduction of PPARactivity on -cell function, we investigated insulin secretion in PPAR / mice on a high-fat diet. Glucoseinduced insulin secretion in PPAR / mice was impaired in vitro. The tissue triglyceride (TG...

Our aim in this study was to create a noninvasive and practical method for evaluating metabolic information on the liver (iron content and lipid infiltration) and spine (bone mineral density and marrow fat degeneration) by using double gradient-echo with and without the spectral fat suppression technique (double-GRE-FS). We arranged phantoms made of various concentrations of superparamagnetic i...