UNLABELLED The pathogenesis of accelerated liver damage in subjects coinfected with hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) remains largely unknown. Recent studies suggest that ongoing chronic liver inflammation is responsible for the liver injury in HCV-infected patients. We aimed to determine whether HIV-1 coinfection altered intrahepatic inflammatory profiles ...

OBJECTIVE The objective of this study is to quantitate expression of genes possibly contributing to insulin resistance and fat deposition in the human liver. RESEARCH DESIGN AND METHODS A total of 24 subjects who had varying amounts of histologically determined fat in the liver ranging from normal (n = 8) to steatosis due to a nonalcoholic fatty liver (NAFL) (n = 16) were studied. The mRNA co...

The liver, as the major organ for iron storage and production of hepcidin, plays pivotal roles in maintaining mammalian iron homeostasis. A previous study showed that Quantitative Trait Loci (QTLs) on chromosome 7 (Chr7) and 16 (Chr16) may control hepatic non-heme iron overload in an F2 intercross derived from C57BL/6J (B6) and SWR/J (SWR) mice. In this study, we aimed to validate the existence...

Strains of the food-borne pathogen Listeria (L.) monocytogenes have diverse virulence potential. This study focused on three outbreak strains: CC1 strain PF49 (serovar 4b) from a cheese-associated in Switzerland, clinical CC2 F80594 4b), and G6006 (CC3, serovar 1/2a), responsible for large gastroenteritis USA due to chocolate milk. We analysed genomes characterized vitro vivo. Whole-genome sequ...

The scientific review presents the mechanisms of action intranuclear miRNAs, namely microRNA-mediated regulation non-coding RNA (ncRNA) transcriptome and alternative splicing. To write article, information was searched using Scopus, Web Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, Cochrane Library, CyberLeninka databases. It is emphasized that a significant effect on composi...

Liver metabolism and health in dairy cows during the periparturient period are affected by plane of nutrition prepartum. Long-term adaptations in hepatic gene expression are important for complete understanding of liver function. We examined temporal gene expression profiles during the dry period and early lactation in liver of Holstein cows fed moderate dietary energy ad libitum or restricted ...

PM 2.5 can cause adverse health effects via several pathways, such as inducing pulmonary and systemic inflammation, penetration into circulation, activation of the autonomic nervous system. In particular, impact exposure on liver, which plays an important role in metabolism detoxification to maintain internal environment homeostasis, is getting more attention recent years. present study, C57BL/...

BACKGROUND Reference genes serve an important role as an endogenous control/standard for data normalisation in gene expression studies. Although reference genes have recently been suggested for marsupials, independent analysis of reference genes on different immune tissues is yet to be tested. Therefore, an assessment of reference genes is needed for the selection of stable, expressed genes acr...

Abstract Fetal adaptations to nutrition in utero lead long-term effects on fetal growth and postnatal performance. Although required minute amounts, minerals play an essential role programming, likely through epigenetic mechanisms. Thus, changes the embryonic epigenome modulate gene transcription and, consequently, differentiation, growth, development of cells tissues. Despite growing knowledge...