Sodium arsenite (NaAsO₂) has been recognized as a worldwide health concern. Hydrangea macrophylla (HM) is used as traditional Chinese medicine possessing antioxidant activities. The study was performed to investigate the therapeutic role and underlying molecular mechanism of HM on NaAsO₂-induced toxicity in human liver cancer (HepG2) cells and liver in mice. The hepatoprotective role of HM in H...

BACKGROUND Steatosis is common in patients with hepatitis C virus (HCV) infection and may be a major determinant of progression of liver injury. This study evaluated FibroMax™ for noninvasive diagnosis of steatosis in patients with chronic HCV. METHODS This cross-sectional study included 44 patients naïve to treatment who were referred to our hepatology clinic for assessment of fitness for an...

We sought to investigate anticancer efficacy of a vascular disrupting agent (VDA) combretastatin A-4 phosphate (CA4P) in relation to tumor size among hepatocellular carcinomas (HCCs) in rats using magnetic resonance imaging (MRI) and postmortem techniques. Nineteen rats with 43 chemically-induced HCCs of 2.8–20.9 mm in size on liver cirrhosis received CA4P intravenously at 10 mg/kg. Tumor-diame...

BACKGROUND AND AIMS Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of HCV infection as well as outcome following peginterferon and ribavirin therapy among HCV genotype 1 infected patients. The present study aimed to evaluate the impact of IL28B SNP variability on liver histology in t...

The objective of the study was to compare the sensitivity of wild and laboratory-bred bank voles to cadmium (Cd)-induced histopathological changes in the liver and kidneys. For 4 weeks, the male bank voles-both wild and laboratory-bred-were provided with diet containing Cd in quantities <0.1 (control), 30, and 60 μg/g dry weight. At the end of exposure period, histopathology and analyses of Cd,...

BACKGROUND Short-term administration of Galactosamine to experimental animals causes liver damage and acute liver failure (ALF), as well as acute renal failure in some cases. The aim of our study was to describe kidney disorders that developed in the course of galactosamine-induced liver failure. MATERIAL AND METHODS Sprague-Dawley rats were randomly divided into 2 groups: a study group admin...

This study aimed to investigate the antioxidant and hepatoprotective effects of Celtis tournefortii fruit extract (Ct) against copper-induced liver damage in rats. Thirty-two Wistar Albino rats were divided into four equal groups (n = 8): Control, Copper (Cu), + C. (Cu+Ct), (Ct). Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activities, (GSH) concentration, malondiald...

The aim of this study was to evaluate small doses of known cytochrome P450 enzyme inhibitors, grapefruit juice (GFJ) and one of its components, bergamottin (BGT), for the prevention of paracetamol (PAR)-induced hepatotoxicity after overdose in rats. Six groups of 15 Sprague Dawley (SD) rats each were treated with single oral doses of either saline, PAR only 1725 mg/kg, PAR + GFJ low dose (2 ml)...

Correspondence: Dina Sabry Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Al Kasr Al Aini Hospital, Al Kasr Al Aini Street, Giza, Egypt Tel +20 11 1120 0200 Fax +1 202 2363 2297 Email [email protected] Background: Steatosis is common in patients with hepatitis C virus (HCV) infection and may be a major determinant of progression of liver injur...

Azadirachta indica A. Juss or neem is herbal that contains antioxidants and bioactive compounds of alkaloids, steroids, flavonoids, saponins tannins can play a role in various biological activities. The purpose this study was to determine the effect water extract leaves mixed drinking on liver health performance KUB chickens. observed variables were serum glutamate pyruvate transaminase (SGPT) ...