The in vitro and in vivo incorporation of (2-14C)acetate into lipids of mink (Mustela vison) liver and intestines was studied. In vitro, a dose of aflatoxin B1 as small as 7.5 mug/ml of medium reduced by 20% the amount of (2-14C)acetate incorporated into lipids of mink liver slices, whereas 180 mug caused 76% reduction in the synthesis of lipids from the radioactive precusor. Similar inhibition...

Mancozeb, a fungicide of ethylenebisdithiocarbamate group was orally administered at doses of 500, 600, 700 and 800 mg/kg body weight/day to normal virgin rats of Wistar strain for 30 days. The vaginal smear and body weight of the rats were recorded daily and rats were sacrificed on 31st day. Estrous cycle was effected by showing a significant decrease in the number of estrous cycle, duration o...

ROSENTHAL, J., A. ANGEL, AND J. FARKAS. Metabolic fate of leucine: a sign$kant sterol precursor in adipose tissue and muscle. Am. J. Physiol. 226(2) : 411-418. 1974.-The quantitative significance of muscle and adipose tissue as extrahepatic sites of leucine metabolism was studied. The rate of leucine conversion to either CO* or total lipid expressed per gram wet weight of tissue was adipose tis...

The effects of dietary lipid and carbohydrate, and their interaction, on growth performance and body composition of juvenileblunt snout bream Megalobrama amblycephala were investigated. Fish were fed one of eight isonitrogenous (32% crude protein) diets containing 4% or 7% lipids and 25%, 30%, 35%, or 40% carbohydrate for nine weeks. Weight gain, feed conversion ratio, protein efficiency ratio,...

Aim of this work is to present the phenotype and biochemical characteristics primary freshly isolated murine hepatocytes exposed oleic palmitic acids, most abundant fatty acids (FAs) in human diet serum. Excess FAs one factors that contributes non-alcoholic liver disease (NAFLD). The hallmark NAFLD overaccumulation lipids hepatic tissue formation lipid droplets (LDs). With time can progress int...

Background & Objective: Although Pinus eldarica is considered as a pine with many valuable phytochemical constituents, little is known about the pharmacological effects of its bark extract. Therefore, the present study aimed to evaluate in vivo antioxidant activity and also the possible beneficial effects of the bark extract of P. eldarica on dexamethasone-induced dyslipidemia in rats. Materia...

Lysosomal phospholipases play a critical role for degradation of cellular membranes after their lysosomal segregation. We investigated the regulation of lysosomal phospholipase A1 by cholesterol, phosphatidylethanolamine, and negatively-charged lipids in correlation with changes of biophysical properties of the membranes induced by these lipids. Lysosomal phospholipase A1 activity was determine...

OBJECTIVE—Ectopic lipid storage in muscle (intramyocellular lipids [IMCL]) and liver (hepatocellular lipids [HCL]) coexists with impaired myocellular flux through ATP synthase (fATPase) in certain cohorts with increased risk of type 2 diabetes. Because women with a history of gestational diabetes (pGDM) have elevated ectopic lipids and diabetes risk, we tested whether deteriorated energy metabo...

Purpose: Aging is related to multiple and systemic dysfunctions in the body, accompanied by metabolic disorders oxidative stress. Although studies are revealing role of endoplasmic reticulum (ER) stress aging-related pathologies, this relationship has not been fully elucidated. In study, it was aimed reveal changes liver function, plasma lipids, markers due aging gender, investigate how these p...

BACKGROUND Hepatic steatosis is defined as excessive amounts of triglyceride and other fats inside liver cells and has become an emergent liver disease in developed and developing countries. METHODS Deep seawater (DSW)300, DSW900, and DSW1500 drinking waters were formulated via a combination of reverse osmosis and electrodialysis. Hamsters on a high-fat diet were assigned to drink the followi...