We have investigated the presence and the possible clinical implications of oxidative stress in children with non-alcoholic fatty liver disease (NAFLD). The present study was an observational study of oxidative stress parameters in the progression of paediatric NAFLD. We observed the role of oxidative stress in children diagnosed with NAFLD by evaluating: serum protein carbonyls, hepatic expres...

Lead a divalent cation has long been recognized as an ubiquitous pollutant of the eco-system. Occupational exposure to lead is the most common cause of elevated blood lead levels, (BLL). Occupational exposure to lead has been associated globally with adverse health effects. This study was designed to ascertain if some occupational exposure to lead in Nigeria results in elevated blood lead level...

Liver biopsy and histopathological evaluation are the main methods to assess liver pathology. However, liver biopsy is not widely used due to implementation challenge. We aimed to investigate non-invasive parameters for evaluation of liver fibrosis in chronic Hepatitis B patients. A total of 65 patients who admitted to outpatient clinic and diagnosed as chronic hepatitis were included in this s...

Background: The feasibility of using elasticity imaging techniques for high–intensity–focused–ultrasound (HIFU) ablation monitoring and assessment has been previously demonstrated both in vitro and in vivo (e.g. [1,2]). Nonetheless, effective use of these techniques requires quantitative assessment of the changes in the mechanical properties of the ablated tissue during the treatment process. T...

Development of a safe and effective method for gene delivery to hepatocytes is a critical step toward gene therapy for liver diseases. Here, we assessed the parameters for gene delivery to the livers of large animals (pigs, 40-65 kg) using an image-guided hydrodynamics-based procedure that involves image-guided catheter insertion into the lobular hepatic vein and hydrodynamic injection of repor...

Several human diseases including, cancer, rheumatoid arthritis, neurodegenerative and hepatic diseases are related to destructive effect of reactive oxygen species (ROS). Antioxidants may provide a possible solution to this problem.This study was carried out to investigate the effect of hydroalcoholic extract of Celtis australis on CCl4 induced hepatotoxicity in mice.  The antioxidant activity...

Teucrium polium is an analgesic, antidiabetic and antilipeidemic herbal medicament. The aim of this survey was to evaluate the effect of aqueous extract T. polium on liver enzymes linked to liver dysfunction, serum lipids and glucose, in diabetic male rats. Methods: A total of 20 Sprague-Dawly male rats became diabetic by intraperitoneal injection of streptozotocin (60 mg/kg). the animals were ...

Abstract Background β−Thalassemic children have oxidative stress and antioxidant deficiency even without iron overload status. In these patients, tissue damage due to oxidative stress may be occurred. Also, it seems that thalassemic patients have higher levels of ALT, AST therefore, the main aim of the present study was to determine the benefits of vitamin E as an antioxidant supplements in β...

teucrium polium is an analgesic, antidiabetic and antilipeidemic herbal medicament. the aim of this survey was to evaluate the effect of aqueous extract t. polium on liver enzymes linked to liver dysfunction, serum lipids and glucose, in diabetic male rats. methods: a total of 20 sprague-dawly male rats became diabetic by intraperitoneal injection of streptozotocin (60 mg/kg). the animals were ...

OBJECTIVES To evaluate whether chronic therapy with probiotics affects plasma levels of cytokines and oxidative/nitrosative stress parameters, as well as liver damage, in patients with various types of chronic liver disease. PATIENTS AND METHODS A total of 22 nonalcoholic fatty liver disease (NAFLD) and 20 alcoholic liver cirrhosis (AC) patients were enrolled in the study and compared with 36...