Abstract Marine organisms have attracted considerable attention in recent years. In this study, peptides with osteogenic activity from Pinctada martensii were isolated and identified. Additionally, the effects of hydrolysates on MC3T3-E1 cell proliferation differentiation evaluated using MTT alkaline phosphatase (ALP) assays, respectively. First, trypsin, pancreatin, neutral protease used to hy...

On the basis of the inhibition of double strand DNA (dsDNA)-templated fluorescent copper nanoparticles (CuNPs) by pyrophosphate (PPi), a novel label-free turn-on fluorescent strategy to detect alkaline phosphatase (ALP) under physiological conditions has been developed. This method relies on the strong interaction between PPi and Cu(2+), which would hamper the effective formation of fluorescent...

Abnormalities of bone mineral metabolism and vascular calcification are prevalent in patients with kidney failure. Clinical management is based on biochemical targets, in particular parathyroid hormone (PTH) concentrations, but this has many limitations including high biological variation. A possible alternative is bone-specific alkaline phosphatase (ALP); therefore, we evaluated the biological...

The relationship between serum alkaline phosphatase (ALP) concentrations and mortality in peritoneal dialysis (PD) patients is rarely reported. We enrolled 667 PD patients in one PD centre in Taiwan to retrospectively examine the association between three ALP concentrations (baseline, time-averaged, time-dependent) and mortality over a 5-year period (2011-2015). Baseline data collection include...

Microbial enzymes produced using biological processes are of great importance due to their contribution sustainable solutions for agricultural production. In our previous study, the chitinase enzyme from Lactobacillus coryniformis was purified, immobilized zinc oxide (ZnO) nanoparticles, and its effectiveness as a bioinsecticide against storage pest Sitophilus zeamais Motschulsky, 1855 (Coleopt...

BACKGROUND It is demonstrated that elevated serum levels of alkaline phosphatase (ALP) and phosphate indicate a higher risks of cardiovascular disease (CVD) and total mortality in population with chronic kidney disease (CKD), but it remains unclear whether this association exists in people with normal or preserved renal function. METHOD Clinical trials were searched from Embase and PubMed fro...

INTRODUCTION AND OBJECTIVE Mandible is used as a bone model for monitoring bone tissue responses to various factors influencing skeletal homeostasis. Considering the lack of experimental data on interrelationships between bone metabolism indices and morphometric, densitometric and mechanical properties of mandible, the aim of this study was to perform such an evaluation in 6-month-old pigs. M...

BACKGROUND Alkaline phosphatase (ALP) is an important enzyme mainly derived from the liver, bones and in lesser amounts from intestines, placenta, kidneys and leukocytes. An increase in ALP levels in the serum is frequently associated with a variety of diseases. This study was done in order to determine the diseases associated with a high ALP level among Thai adult hospitalized patients. METH...

Heteropneustes fossilis (Heteropneustidae) is an air breathing freshwater catfish, has an ever increasing demand as a major source of protein and vitamin A. Acid precipitation has detrimental effect on fish population. We have investigated the activity and localization of the enzyme alkaline phosphatase (ALP), by means of histochemical study on experimental wound repair in the fish skin under a...

Transport of proteins through the ALP (alkaline phosphatase) pathway to the vacuole requires the function of the AP-3 adaptor complex and Vps41p. However, unlike other adaptor protein-dependent pathways, the ALP pathway has not been shown to require additional accessory proteins or coat proteins, such as membrane recruitment factors or clathrin. Two independent genetic approaches have been used...